VISUAL-MOTOR TRANSFORMATIONS IN PARIETAL CORTEX

顶叶皮层的视觉运动转换

• 批准号: 6350875
• 负责人: Lawrence H Snyder
• 金额: $ 23.89万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6350875
• 关键词: Primates; arm; behavior test; body movement; brain mapping; eye movements; head movements; limb movement; neural information processing; parietal lobe /cortex; sensorimotor system; space perception; visual stimulus

DESCRIPTION (Adapted From The Applicant's Abstract): This proposal will investigate the role of the posterior parietal cortex in directing movements to visible targets. The parietal cortex clearly plays a role in this process, but the nature of that role is unresolved. Complicating the issue is the fact that parietal cortex contains multiple fields, many of which are involved in the processing of visual spatial information, and some of which appear to be related to the movements of particular body parts. A common approach to studying the role of these fields in transforming sensory information into motor commands has been to consider the frame of reference of the spatial information that each contains. The PI now proposes to study, in addition, whether and how the information is specifically related to arm, eye and head movements (motor specificity). The development of motor specific responses relates to the selection of a particular motor response, a critical stage in the sensory to motor transformation. It is suggested that response selection and reference frame transformation are two distinct and potentially separable components of that transformation. This approach is a significant departure from previous work, which has typically considered only a single motor output. Aim I will characterize the exact relationship between motor specificity and frame of reference for activity in the ventral intraparietal area (VIP). The experiments and their analysis are designed to capture the full range and potential richness of the properties of individual neurons, rather than merely categorizing them as "motor" or "sensory." Aim 2 will examine motor-specific activity in the lateral intraparietal area (LIP) and in the parietal reach region (PRR). We will determine how signals encoding the decision to take one course of action or another interact with signals encoding spatial information. Finally, Aim 3 will challenge an established hypothesis concerning spatial information processing in LIP. The hypothesis has important ramifications for whether processing may be directed towards specific motor outputs. Taken together, the results of these aims are likely to provide new insight into the role of parietal cortex in the sensory to motor transformation in general, and in particular, into the role of specific fields in directing eye, arm and head movements to visual targets.

描述（改编自申请人的摘要）：该提案将 研究后顶叶皮层在指导运动中的作用 可见的目标。顶叶皮层显然在这个过程中发挥了作用，但是 该角色的性质尚未确定。使问题变得复杂的事实是 顶叶皮层包含多个区域，其中许多区域涉及 视觉空间信息的处理，其中一些似乎是 与特定身体部位的运动有关。一个常见的方法是 研究这些场在将感官信息转化为 运动指令一直要考虑空间的参考系 每个包含的信息。此外，PI 现在建议研究： 这些信息是否以及如何与手臂、眼睛和头部具体相关 运动（运动特异性）。运动特异性反应的发展 涉及特定运动反应的选择，这是运动中的关键阶段 感觉到运动的转变。建议选择响应 和参考系变换是两个不同且可能可分离的 该转变的组成部分。这种方法是一个重大背离 以前的工作通常只考虑单个电机输出。 目标 我将描述运动特异性和运动特异性之间的确切关系 腹侧顶内区（VIP）活动的参考框架。这 实验及其分析旨在捕获全范围和 单个神经元特性的潜在丰富性，而不仅仅是 将它们分类为“运动”或“感觉”。目标 2 将检查特定运动 顶叶外侧区 (LIP) 和顶叶区域的活动 区域（PRR）。我们将确定信号如何编码采取一项决定 行动过程或其他与编码空间信息的信号相互作用。 最后，目标 3 将挑战有关空间的既定假设 LIP 中的信息处理。该假设具有重要影响 处理是否可以针对特定的电机输出。采取 总之，这些目标的结果可能会为人们提供新的见解 顶叶皮层在感觉到运动转换中的一般作用，以及 特别是特定领域在引导眼睛、手臂和头部方面的作用 移动到视觉目标。