Pleiotropy for Alcohol-Related Phenotypes

酒精相关表型的多效性

• 批准号: 6404724
• 负责人: JEREMY C OWENS
• 金额: $ 2.39万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-08 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6404724
• 关键词: alcoholism /alcohol abuse; behavioral /social science research tag; behavioral genetics; laboratory mouse; molecular genetics; phenotype; pleiotropism; predoctoral investigator

The major objective of this research proposal is to find the gene(s) underlying alcohol-related phenotypes in mice (but also in humans). To study these phenotypes I will use congenic-mice, which carry genes or quantitative trait loci for differences in loss of righting reflex induced by ethanol. Finding other alcohol related phenotypes that are affected by the genes being carried by the congenics would narrow the locus of control for these phenotypes to the congenic region. This strategy will be most successful if the gene specifying loss of righting reflex has pleiotropic effects on other alcohol related phenotypes such as lowdose ethanol-induced activation. Finding more than one phenotype specified by one gene will implicate a common neural system in different alcohol-related phenotypes. Finding this common system would allow for better understanding and treatment in alcohol-abusing human populations. Even if different genes specify low-dose ethanol-induced activation and loss of righting reflex, we will gain an understanding of the genetics of low-dose ethanol-induced activation.

这项研究计划的主要目标是找到小鼠（以及人类）酒精相关表型背后的基因。为了研究这些表型，我将使用同类小鼠，它们携带乙醇诱导的翻正反射丧失差异的基因或数量性状基因座。找到受同类基因携带的基因影响的其他酒精相关表型，会将这些表型的控制范围缩小到同类区域。如果指定翻正反射丧失的基因对其他酒精相关表型（例如低剂量乙醇诱导的激活）具有多效性作用，则该策略将是最成功的。发现一个基因指定的多个表型将暗示不同的酒精相关表型中有一个共同的神经系统。找到这个共同系统将有助于更好地理解和治疗酗酒人群。即使不同的基因指定低剂量乙醇诱导的激活和翻正反射的丧失，我们也将了解低剂量乙醇诱导的激活的遗传学。