CONTROLLED HEAT-AIDED TRANSDERMAL DRUG DELIVERY:FENTANYL

受控热辅助透皮给药：芬太尼

• 批准号: 6210185
• 负责人: JIE ZHANG
• 金额: $ 14.22万
• 依托单位: ZARS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6210185
• 关键词: analgesics; clinical research; drug design /synthesis /production; fentanyl; heat stimulus; human subject; method development; pain; transdermal drug delivery

DESCRIPTION (Adapted from the application): The investigators believe the fentanyl transdermal patch currently available has several limitations including the requirement of a long time to reach peak effect and that it cannot be used to treat breakthrough pain (short-lasting episodes of increased pain). ZARs' preliminary data, using its patented controlled, heat-aided drug delivery (CHADD) technology has demonstrated an ability to significantly enhance the dermal absorption of fentanyl from commercially available fentanyl skin patches. The aim of the proposed research is to develop a CHADD system that can significantly shorten the time it takes a fentanyl skin patch to reach peak effect and to prove the concept that CHADD can be utilized to produce a rapid bolus of fentanyl from skin patches, sufficient to treat breakthrough pain. PROPOSED COMMERCIAL APPLICATION: The commercial product will be prescribed by doctors for the treatment of both chronic pain (including severe cancer-related pain) and breakthrough pain (short-lasting episodes of increased pain).

描述（改编自申请）：研究人员认为 目前可用的芬太尼透皮贴剂有几个局限性 包括需要很长时间才能达到峰值效果，并且 不能用于治疗爆发性疼痛（短暂发作的疼痛加剧 疼痛）。 ZARs 的初步数据，使用其专利受控热辅助药物 交付（CHADD）技术已被证明能够显着增强 市售芬太尼皮肤对芬太尼的皮肤吸收 补丁。拟议研究的目的是开发一个 CHADD 系统，该系统可以 显着缩短芬太尼皮肤贴剂达到峰值所需的时间 效果并证明CHADD可用于产生快速的概念 从皮肤斑块中注射芬太尼，足以治疗突发性疼痛。 拟议的商业应用： 该商业产品将由医生开处方用于治疗慢性病 疼痛（包括与癌症相关的严重疼痛）和爆发性疼痛（短暂发作 增加疼痛）。