Comorbid Disorders in Treatment of Opiate Dependence

阿片依赖治疗中的共病

• 批准号: 6515916
• 负责人: GERARDO GONZALEZ-HADDAD
• 金额: $ 13.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515916
• 关键词: cocaine; comorbidity; depression; desipramine; drug abuse; drug abuse chemotherapy; endogenous opioid; health care cost /financing; human subject; human therapy evaluation; neuropharmacology; patient oriented research; sertraline

DESCRIPTION: (Provided by Applicant) This application is to study comorbid disorders that affect the treatment of opiate dependence. The specific aims of the proposed program of research are as follows: Study 1 will examine comorbid depression as a predictive factor in treatment with desipramine and contingency management of cocaine abusing opiate dependent subjects maintained on buprenorphine by secondary data analysis of a completed randomized clinical trial. Study 2 will evaluate the efficacy of sertraline in the treatment of cocaine dependent patients with comorbid depression in a recently started double-blind randomized clinical trial. Study 3 will determine changes of health care cost after treatment of opiate dependence in the Veterans Affairs health delivery system using existing administrative databases. It will determine whether confounding factors, especially comorbid depression and cocaine dependence, may affect changes in costs. The overall aim of the proposal is to provide me with a supervised patient oriented research and educational experience that will enable me to become an independent investigator in substance abuse. My specific career development goals are to: (1) Acquire in-depth knowledge of the neuropharmacology of cocaine and opiate dependence, and of substance induced mood disorders. (2) Develop expertise in clinical research and management of cocaine and opiate dependence, and current pharmacotherapies. (3) Develop skills in Mental Health Service research related to substance abuse. The proposed career development plan utilizes the collaboration of Thomas Kosten, MD in developing expertise executing randomized clinical trials, Robert Rosenheck, MD in developing skills in mental health services research and Kevin Sevarino, MD, PhD in clinical management of opiate dependence. The educational experience includes a four year period of formal coursework at the Interdepartmental Neuroscience Program at the Yale School of Medicine and at the Yale School of Epidemiology and Public Health. This K23 research career award will enable me to start an academic career focusing on research in cocaine and opiate dependence and to develop a bridge between clinical trials and services research.

描述：（申请人提供） 该应用是研究影响治疗治疗的合并症 鸦片依赖。拟议的研究计划的具体目的是 以下内容：研究1将检查合并抑郁作为预测因素 可卡因滥用阿片类药物的去丙胺和应急管理治疗 通过二级数据分析A 完成了随机临床试验。研究2将评估 可卡因依赖性患者合并症治疗的舍曲林 最近开始的双盲随机临床试验中的抑郁症。学习 3将确定治疗阿片类药物后的医疗保健成本的变化 使用现有 管理数据库。它将决定是否混淆因素， 特别是合并症抑郁症和可卡因依赖性，可能会影响 费用。该提案的总体目的是为我提供监督 以患者为导向的研究和教育经验，这将使我能够 成为滥用药物的独立研究者。我的特定职业 发展目标是：（1）获得深入了解 可卡因和鸦片依赖性的神经药理学以及物质诱导的 情绪障碍。 （2）在临床研究和管理方面发展专业知识 可卡因和鸦片依赖性以及当前的药物疗法。 （3）发展 精神卫生服务研究技能与药物滥用有关。这 拟议的职业发展计划利用托马斯·科斯顿（Thomas Kosten）的合作 MD在开发执行随机临床试验的专业知识方面，罗伯特 医学博士罗森海克（Rosenheck）开发精神卫生服务研究技能和凯文（Kevin） 塞瓦里诺（Sevarino），医学博士，博士学位，用于鸦片依赖的临床管理。教育 经验包括四年的正式课程。 耶鲁大学医学院和在 耶鲁大学流行病学与公共卫生学院。这个K23研究生涯 奖项将使我能够开始专注于研究的学术职业 可卡因和鸦片依赖性，并在临床试验之间开发桥梁 和服务研究。