Point of Care Blood Cell Analysis

护理点血细胞分析

• 批准号: TS/G001405/1
• 负责人: Hywel Morgan
• 金额: $ 96.11万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=TS%2FG001405%2F1
• 关键词: Point; Care; Blood; Cell; Analysis

The project will develop a new micro-technology for label-free point of care (PoC) cell analysis, paying particular attention to accurate determination of low abundance cell populations for a five-part differential for full blood count (FBC). The FBC is the single most common clinical measurement used to provide information on a patient's health in almost every single disease, indicating the large commercial impact of the work proposed here. The project will also develop new low pressure, low power microfluidics, minimally invasive sample extraction and low-volume processing and new integrated electronics. We will also develop methods for meaningful information delivery to patient and doctor. The end-results will be solutions and know-how for implementation of a handheld PoC Full Blood Count (FBC) system, based on high speed single cell impedance spectroscopy in a microfluidic format. This project will provide breakthroughs in functionality, minaturisation and consumer acceptability to realise a true PoC FBC.

该项目将开发一种用于无标签护理点（POC）细胞分析的新的微技术，特别注意准确地确定五部分差异的低丰度细胞种群（FBC）。 FBC是用于在几乎每种疾病中提供有关患者健康的信息的最常见临床测量，表明此处提出的工作对商业影响很大。该项目还将开发新的低压，低功率微流体，微创样品提取和低容量处理以及新的集成电子产品。我们还将开发向患者和医生提供有意义的信息的方法。最终结果将是基于高速单细胞阻抗光谱谱以微流体格式的高速单细胞阻抗光谱的实现的解决方案和专有技术。该项目将在功能，微饱和度和消费者的可接受性方面提供突破性，以实现真正的POC FBC。

项目成果

Microfluidic impedance cytometry of tumour cells in blood.

• DOI: 10.1063/1.4904405
• 发表时间: 2014-12
• 期刊: Biomicrofluidics
• 影响因子: 3.2
• 作者: D. Spencer;Veronica Hollis;H. Morgan

Comparison of venous and capillary differential leukocyte counts using a standard hematology analyzer and a novel microfluidic impedance cytometer.

• DOI: 10.1371/journal.pone.0043702
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hollis VS;Holloway JA;Harris S;Spencer D;van Berkel C;Morgan H
• 通讯作者: Morgan H