Career Training in Marijuana Dependence

大麻依赖的职业培训

• 批准号: 6531403
• 负责人: AIMEE L MCRAE-CLARK
• 金额: $ 11.2万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-29 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6531403
• 关键词: anxiety; behavior therapy; behavioral /social science research tag; buspirone; cannabinoids; clinical research; clinical trial phase I; combination therapy; craving; drug abuse chemotherapy; drug screening /evaluation; human subject; human therapy evaluation; marijuana abuse; mood disorders; motivation; patient oriented research; pharmacokinetics; urinalysis

DESCRIPTION (provided by applicant): This application for a Mentored-Patient Oriented Research Career Development Award is designed to prepare the candidate for a career in clinical research in drug use disorders with a special emphasis on marijuana use, abuse, and dependence. The training plan involves course work, supervised readings, and "hands on" experience with leading experts in the pharmacology of cannabinoids and the treatment of marijuana dependence. There is a disconnect between the advances in the pharmacology and basic science of cannabinoids and clinical research in this area. By studying both basic science and clinical aspects, the candidate will be well-positioned to design and carry out methodologically sound patient-oriented research with a strong theoretical background. Developing this well-rounded perspective and expertise in the area of cannabinoids and marijuana abuse and dependence is the aim of the training plan outlined. The proposed research project integrates the candidate's experience in conducting pharmacotherapeutic trials with newly developed skills in motivational interviewing. The clinical research that has been conducted in the area of marijuana use and dependence has almost exclusively focused on psychotherapeutic interventions, including motivational interviewing. However, recent neuroscientific advances, such as the discovery of the cannabinoid receptors, suggest that pharmacotherapeutic strategies for treating marijuana dependence should be explored in conjunction with psychotherapeutic interventions. As anxiety may play a key role in marijuana abuse anxiolytic medications in particular may prove useful in reducing marijuana use. The hypothesis to be tested in the proposed research project is whether buspirone, an anxiolytic medication, will increase efficacy in reducing marijuana use in marijuana-dependent patients when delivered with motivational interviewing. The study will be a 12-week, randomized, double-blind, placebo-controlled trial evaluating a flexible dose of buspirone or placebo in combination with motivational interviewing. The primary outcome measure will be marijuana use as assessed by self-report and weekly urine drug screens. The results of this study will help guide future directions for research in the area of marijuana dependence.

描述（由申请人提供）：本申请以指导患者为导向的研究职业发展奖旨在帮助候选人为药物使用障碍的临床研究职业做好准备，特别强调大麻的使用、滥用和依赖。 培训计划包括课程作业、监督阅读以及大麻素药理学和大麻依赖治疗领域领先专家的“实践”经验。 大麻素的药理学和基础科学的进步与该领域的临床研究之间存在脱节。 通过研究基础科学和临床方面，候选人将能够以强大的理论背景设计和开展方法论上合理的以患者为导向的研究。 概述的培训计划的目的是在大麻素和大麻滥用和依赖领域发展这种全面的观点和专业知识。 拟议的研究项目将候选人进行药物治疗试验的经验与新开发的动机访谈技能相结合。 在大麻使用和依赖领域进行的临床研究几乎完全集中在心理治疗干预上，包括动机访谈。 然而，最近的神经科学进展，例如大麻素受体的发现，表明治疗大麻依赖的药物治疗策略应与心理治疗干预措施结合起来探索。 由于焦虑可能在大麻滥用中发挥关键作用，抗焦虑药物尤其可能有助于减少大麻的使用。 在拟议的研究项目中要测试的假设是，在进行动机访谈时，丁螺环酮（一种抗焦虑药物）是否会提高减少大麻依赖患者吸食大麻的功效。 该研究将是一项为期 12 周的随机、双盲、安慰剂对照试验，评估灵活剂量的丁螺环酮或安慰剂与动机访谈的结合。 主要结果指标将是通过自我报告和每周尿液药物筛查评估的大麻使用情况。 这项研究的结果将有助于指导大麻依赖领域未来的研究方向。