REGIONAL VARIATIONS IN BREAST CANCER RATES IN CALIFORNIA

加利福尼亚州乳腺癌发病率的地区差异

• 批准号: 6377257
• 负责人: Peggy Reynolds
• 金额: $ 48.74万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377257
• 关键词: United States; biomarker; breast neoplasms; cancer risk; carbopolycyclic compound; clinical research; cooperative study; data collection methodology /evaluation; diet; disease /disorder etiology; environmental toxicology; family genetics; female; geographic site; human data; human morbidity; human mortality; human population study; human subject; interview; nutrition related tag; phytoestrogens; questionnaires; rural area; socioeconomics; urban area; urinalysis; women's health; United States; biomarker; breast neoplasms; cancer risk; carbopolycyclic compound; clinical research; cooperative study; data collection methodology /evaluation; diet; disease /disorder etiology; environmental toxicology; family genetics; female; geographic site; human data; human morbidity; human mortality; human population study; human subject; interview; nutrition related tag; phytoestrogens; questionnaires; rural area; socioeconomics; urban area; urinalysis; women's health

Observed regional variations in breast cancer incidence have been a source of public health concern as well as traditionally a source of hypothesis generation for factors which might be implicated in disease etiology. Rate differences within California are similar to differences noted on the national scale. This proposal is designed to explore factors that may explain the observed regional variations within California. The specific aims of the study are to: use a geographic information system (GIS) and grouped data sources to evaluate the potential influence of sociodemographic factors (e.g., income, education), environmental toxicants(e.g., pesticides, automobile exhaust), and established risk factors (e.g., family history, reproductive risk factors) on regional differences in breast cancer incidence rates in California; further evaluate regional associations identified in Aim 1 by incorporating individual risk factor information from a large, prospective cohort study of California teachers specifically designed to study risk factors for breast cancer; and conduct a biomarker substudy targeted at exploring urban/rural variations in biological markers of two specific exposures of emerging interest in breast cancer research (i.e, phytoestrogens and polycyclic aromatic hydrocarbons). Statewide grouped analyses will rely on multiple sources of data including the largest cancer registry in the world, two statewide risk factor surveys, multiple statewide environmental datasets, and census data. Individual-level risk factor information will be derived from the 133,400 female teachers enrolled in the California Teacher Studies (CTS) cohort who are geographically dispersed throughout the state. The biomarker substudy will be nested within this cohort and will be conducted on 130 urban and 130 rural CTS members to evaluate both dietary and environmental markers for exposures potentially related to regional variations in breast cancer. These multiple sources of data, coupled with the use of a GIS system, offer a unique opportunity to integrate individual risk factor information with potentially important community-level factors in a way that no other study has done to date. Furthermore, the biomarker substudy will allow us to evaluate two emerging and intriguing hypotheses regarding breast cancer etiology in the context of urban/rural variations in breast cancer rates.

观察到的乳腺癌发病率的区域差异一直是公共卫生问题的根源，传统上是可能与疾病病因有关的因素的假设产生来源。 加利福尼亚州内部的差异类似于国家规模上提到的差异。 该提案旨在探索可能解释加利福尼亚州内观察到的区域变化的因素。 该研究的具体目的是：使用地理信息系统（GIS）和分组数据源来评估社会人口统计学因素（例如收入，教育），环境有毒物质（例如，农药，汽车排气）的潜在影响，以及确定的风险因素（例如，家庭历史，家族历史，生殖风险因素）对乳腺癌的危险因素（例如，家族病史，家族历史，生殖风险因素）对乳腺癌的差异;进一步评估AIM 1中确定的区域协会，通过从一项针对研究乳腺癌危险因素的加利福尼亚州教师进行的大型，前瞻性队列研究中纳入个人风险因素信息；并进行生物标志物的物质，用于探索两种在乳腺癌研究中新兴兴趣（即植物雌激素和多环芳族烃）的生物标记中的城市/农村变化。全州范围的分析将依靠多种数据来源，包括世界上最大的癌症注册表，两项全州风险因素调查，多个全州环境数据集和人口普查数据。 个人级别的风险因素信息将来自加利福尼亚教师研究（CTS）同伙的133,400名女教师，这些女教师在整个州遍布地理位置。 生物标志物的质谱将嵌套在该队列中，并将在130个城市和130个农村CTS成员上进行，以评估饮食和环境标志物，以实现与乳腺癌区域变异有关的暴露。 这些多个数据来源，再加上GIS系统的使用，提供了一个独特的机会，可以将个人风险因素信息与潜在的重要社区级别的因素整合在一起，以迄今为止其他研究的方式。 此外，生物标志物的属性将使我们能够评估两个关于乳腺癌病因的新兴和有趣的假设，这些假设在乳腺癌率的城市/农村差异背景下。