CLINICAL RESEARCH IN STEM CELL TRANSPLANTATION

干细胞移植的临床研究

• 批准号: 6377152
• 负责人: SCOTT I BEARMAN
• 金额: $ 12.47万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-14 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377152
• 关键词: autologous transplantation; breast neoplasms; carmustine; cis platinum compound; clinical research; clinical trial phase I; cyclophosphamide; homologous transplantation; human subject; human therapy evaluation; metastasis; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; radionuclides; stem cell transplantation; yttrium

The ongoing work and the proposed studies described in this application have, as a common theme, the use of immunotherapy as an adjunct to high-dose chemotherapy for patients with advanced or high-risk primary breast cancer. Three feasibility studies are described which form the basis for the proposed clinical trials, two of which are phase II and one of which is a randomized study. A retrospective analysis performed by Dr. Bearman's fellow, Dr. Yago Nieto, has resulted in the development of a model to predict patients with high-risk primary breast cancer who are at high-risk of relapse after autologous transplant. That model will identify candidates for two of the proposed clinical trials. This application also describes how Dr. Bearman will trainee young investigators in patient-oriented research. The UCHSC Bone Marrow Transplant Program has sufficient patients to conduct these studies, actively conducts both laboratory and clinical research, and is funded by both peer-reviewed and pharmaceutical support. Dr. Bearman will devote 50 percent effort to this 5 year program.

正在进行的工作和拟议的研究中描述的 作为一个共同的主题，应用将免疫疗法用作辅助 高剂量化学疗法，用于晚期或高风险原发性乳房的患者 癌症。 描述了三项可行性研究，这构成了 拟议的临床试验，其中两个是第二阶段，其中一个是 随机研究。 Bearman博士的研究员进行的回顾性分析 Yago Nieto博士已开发了一个模型来预测患者 高风险的原发性乳腺癌在高风险的复发之后 自体移植。 该模型将确定两个的候选人 拟议的临床试验。 该应用程序还描述了Bearman博士 会在以患者为导向的研究中培训年轻的调查员。 UCHSC骨头 骨髓移植计划有足够的患者进行这些研究， 积极进行实验室和临床研究，并由 同行评审和药物支持。 Bearman博士将投入50％ 这项5年计划的努力。