GROUP A STREPTOCOCCAL INFECTIONS IN CHILDREN

儿童 A 组链球菌感染

• 批准号: 6372676
• 负责人: Judith M Martin
• 金额: $ 12.47万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6372676
• 关键词: Streptococcus pyogenes; antibody formation; child (0-11); clinical research; human subject; immunoglobulin A; immunoglobulin G; longitudinal human study; microorganism immunology; mucosal immunity; pharyngitis; saliva

DESCRIPTION (adapted from application abstract): The proposed research is a longitudinal cohort study of school-aged children to define the epidemiology of group A streptococcal pharyngitis. Students in grades K through 8 will be enrolled and throat cultures obtained twice monthly and with each respiratory illness for three years. GAS isolates will be typed by FIGE to determine relatedness and to define infection, carriage, and recurrences. Samples of saliva will be collected for antibody assays and for use in GAS adherence inhibition assays. Baseline, follow-up, and event-specific (e.g., an episode of respiratory infection) clinical information will be collected and analyzed for associations between these variables and protection from or recurrences of GAS pharyngitis. There are four aims: 1) to define the epidemiology of GAS pharyngitis in children; 2) to determine whether specific M-types protect against subsequent infection by GAS with homologous or heterologous M-types; 3) to correlate clinical features that protect against subsequent GAS pharyngitis; and 4) to determine whether saliva produced after GAS infection interferes with adherence of GAS to pharyngeal cell cultures.

描述（根据应用程序摘要改编）：拟议的研究是 对学龄儿童的纵向队列研究定义流行病学 A组链球菌性咽炎。 K年级至8年级的学生将是 注册和喉咙培养每月两次，每种呼吸 病了三年。气体分离株将由Fige键入以确定 相关性并定义感染，运输和复发。样本 唾液将用于抗体测定和用于气体粘附 抑制测定。基线，后续和特定事件（例如，一集 呼吸道感染）将收集和分析临床信息 这些变量与保护与避免或复发之间的关联 气咽炎。有四个目标：1）定义气体的流行病学 儿童咽炎； 2）确定特定的M型是否保护 与随后的气体感染同源或异源M型； 3）关联临床特征以防止随后的气体 咽炎; 4）确定气体感染后是否产生唾液 干扰气体对咽细胞培养物的粘附。