A PROSPECTIVE STUDY OF RISK OF MORTALITY AFTER SCI

SCI 后死亡风险的前瞻性研究

• 批准号: 6388075
• 负责人: JAMES S KRAUSE
• 金额: $ 12.36万
• 依托单位: SHEPHERD CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-10 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6388075
• 关键词: caucasian American; clinical research; ethnic group; functional ability; gender difference; health behavior; human data; human mortality; longitudinal human study; mental health; racial /ethnic difference; spinal cord injury

DESCRIPTION (adapted from investigator's abstract): Previous research through the Model Spinal Cord Injury Systems and a study of British participants with spinal cord injury (SCI) has documented a high prevalence of many deaths after SCI that are preventable (e.g., suicides, septicemia). Research by the principal investigator has indicated that aspects of general adaptation after SCI, including being more active and satisfied with life, are associated with a greater length of survival after SCI (suggesting that poor adaptation underlies many of these types of deaths). Unfortunately, no research has identified the types of stable psychological traits or specific behaviors that either protect the individual for early mortality or that are associated with a greater risk of mortality. Identifying these types of traits and behaviors would establish targets for intervention and prevention that ultimately could lead to greater longevity among people with SCI by reducing the number of deaths due to preventable causes (i.e., those that results from risk behaviors). The purpose of the current proposal is to perform a prospective study of mortality that would identify associations between several sets of factors and early mortality after SCI. Unlike previous research, this study would link traits, behaviors, and health status factors directly to risk for mortality, while maintaining the classification scheme for causes of deaths using the scheme developed with the model SCI systems. The mortality status of 1,391 participants will be determined, all of whom completed a large-scale health survey four years earlier. Biological factors, psychological traits, risk and protective behaviors, and health status and secondary conditions will be assessed. Mortality status will be determined using two national databases - the National Death Index and records from the Social Security Administration. Cox proportional hazard models will be used to identify the significance of individual predictors to compare the importance of classes of predictors, and to identify the optimal predictors of mortality using all predictors. Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity.

描述（根据调查员的摘要改编）：先前的研究 模型的脊髓损伤系统以及对英国参与者的研究 脊髓损伤（SCI）记录了许多死亡的高流行。 可以预防的SCI（例如自杀，败血症）。研究 首席研究人员表明，一般适应的各个方面 SCI，包括对生活更加积极和满意，与 SCI后的生存时间较大（表明适应不良的基础 这些类型的死亡中有许多）。不幸的是，没有研究确定 稳定的心理特征或特定行为的类型 个人死亡率或与更大风险有关的人 死亡率。确定这些类型的特征和行为将建立 干预和预防的目标，最终可能导致更大 通过减少由于 可预防的原因（即由风险行为导致的原因）。目的 当前的建议是对死亡率进行前瞻性研究， 将确定几组因素与早期死亡率之间的关联 科幻之后。与以前的研究不同，这项研究将联系特征，行为， 和健康状况因素直接导致死亡风险，同时保持 使用该计划制定的计划的分类方案 SCI模型系统。 1,391名参与者的死亡率状态将 确定，所有人都完成了四年的大规模健康调查 较早。生物因素，心理特征，风险和保护性 将评估行为，健康状况和次要条件。 死亡率状态将使用两个国家数据库确定 - 国家 死亡指数和社会保障局的记录。考克斯 比例危害模型将用于确定 个人预测因素比较类别的预测因素的重要性，并 使用所有预测因素确定死亡率的最佳预测指标。风险 将生成个人资料以确定早期风险最大的人 死亡。将基于 伤害严重性，性别和种族/种族。