HYBRID MATERIALS FOR DRUG DELIVERY

用于药物输送的混合材料

• 批准号: 6385238
• 负责人: JUSTIN P GALLIVAN
• 金额: $ 3.48万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6385238
• 关键词: acidity /alkalinity; biomaterial development /preparation; copolymer; crosslink; drug delivery systems; gel; physical state

Hydrogels are water swollen networks consisting of crosslinked polymer chains. Recently, hydrogels that respond reversibly to changes in temperature, pH, or the presence of small molecules have been developed. These attractive properties have made reversible hydrogels the subject of intense study for applications ranging from drug-delivery to smart biomaterials that shrink or swell in response to local environmental or physiological changes. The aim of the proposed research is to synthesize triblock copolymers containing both synthetic and protein-based segments. Such materials are expected to behave as reversible hydrogels that display pH and temperature sensitive gelation properties, making them attractive candidates for use in controlled drug delivery. In addition, a strategy is proposed that allows the incorporation of multiple distinct proteins grafted to a polymer backbone. In a broader sense, the proposed research attempts to combine the strongest attributes of modern polymer chemistry and protein-based materials science to produce materials with tunable chemical and biological behavior.

水凝胶是由交联聚合物链组成的水肿胀网络。 最近，已经开发了对温度，pH或小分子的存在的变化的水凝胶。 这些有吸引力的特性使可逆的水凝胶成为了针对从药物传递到智能生物材料的应用的强烈研究的主题，这些应用程序会响应局部环境或生理变化而收缩或膨胀。 拟议的研究的目的是合成含有合成和蛋白质段的三嵌段共聚物。 预计此类材料将表现为可逆水凝胶，这些水凝胶显示出pH和温度敏感的凝胶化特性，使其成为有吸引力的候选者，可用于受控药物输送。 此外，提出了一种策略，该策略允许掺入将多种不同的蛋白掺入接枝到聚合物主链上的策略。 从广义上讲，拟议的研究试图结合现代聚合物化学和基于蛋白质的材料科学的最强属性，以生产具有可调化学和生物学行为的材料。