CONSTRUCTION OF ANIMAL FACILITY

动物设施建设

• 批准号: 6508230
• 负责人: PETER J DAVIES
• 金额: $ 300万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6508230
• 关键词: CONSTRUCTION; ANIMAL; FACILITY; CONSTRUCTION; ANIMAL; FACILITY

DESCRIPTION (provided by applicant): This application requests support for construction of a permanent facility for housing, breeding and care of genetically engineered (transgenic and knockout) and immuno-compromised rodents. The facility will be located in a new research building being designed by the UTHSC-H. UTHSC-H Investigators hold approximately $100 million (total costs) of active National Institutes of Health (NIH)-funding for studies involving animals, and $7 million in yearly direct costs for active and pending studies with specialized mice. Tropical Storm Allison totally destroyed the Animal Care Center that housed most of the animals used for this research. Tragically, hundreds of animals drowned. To prevent this from ever happening again, the proposed facility will be on the top floor of a new nine-story building. The new building will have enclosed connections to the UTHSC-H Medical School and Institute for Molecular Medicine Buildings, so that it will support the work of investigators in all three buildings. The proposed facility will contain 5,945 sq. ft., including a large barrier suite, for genetically engineered and immuno-comprised rodents. It will occupy roughly half a floor devoted exclusively to animal care and accommodate up to 11,000 animals. The facility will be under the control of the Center for Laboratory Animal Medicine and Care (CLAMC), which manages and operates all animal care and use activities at the UTHSC-H. The CLAMC was initially accredited by the AAALAC International in 1978 and remains fully accredited today. The Director of the CLAMC reports directly to the Executive Vice President for Research of the UTHSC-H.

描述（由申请人提供）：本申请要求支持建造永久性设施，用于住房，繁殖和护理基因工程（转基因和淘汰）和免疫功能障碍啮齿动物。 该设施将位于由UTHSC-H设计的新研究大楼中。 UTHSC-H调查人员持有活跃的国家卫生研究院（NIH）的大约1亿美元（总费用），用于涉及动物的研究，以及700万美元的年度直接成本，用于与专业小鼠的活跃和未决研究。 热带风暴艾莉森（Allison）彻底摧毁了容纳大多数用于这项研究的动物的动物护理中心。 可悲的是，数百只动物淹死了。 为了防止这种情况再次发生，拟议的设施将位于新的九层建筑的顶层。 这座新建筑将与UTHSC-H医学院和分子医学建筑研究所建立联系，以便它将支持所有三座建筑物中的调查人员的工作。 拟议的设施将包含5,945平方英尺，包括一个大型屏障套件，用于基因工程和免疫剂的啮齿动物。 它将占用大约一半的楼层，专门用于动物护理，并容纳多达11,000只动物。 该设施将在实验室动物医学与护理中心（CLAMC）的控制下，该中心管理和运营UTHSC-H的所有动物护理和使用活动。 CLAMC最初在1978年获得了AAAALAC国际的认可，并在今天仍然得到完全认可。 CLAMC主任直接向UTHSC-H研究执行副总裁报告。