EXTRAMURAL RES FACIL CONSTRUCTION: ALZHEIMER

外部资源设施建设：阿尔茨海默病

• 批准号: 6794470
• 负责人: JOHN C RUCKDESCHEL
• 金额: $ 15.67万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794470
• 关键词: Alzheimer's disease; animal colony; biomedical facility; building /facility design /renovation; functional /structural genomics; imaging /visualization /scanning; laboratory mouse; pathology

DESCRIPTION (provided by applicant): Support is requested to build out the 29,000 sq. ft. of uninhabitable shell space on the ground level of the new Research Building of the Moffitt Tower Project to establish a 27,683 sq. ft. Mouse Barrier Facility. Capacities of the four existing animal facilities of the centrally administered, AAALAC-accredited program in Tampa Bay, Florida have been exceeded, and all lack a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed facility will correct deficiencies in animal space, and establish space for functional genomic services in a setting of stringent microbiological security. It is ideally located near the greatest focus of federally-funded research involving mice, and adjacent to the area's largest concentration of research laboratory space. It will establish the following: 1) 1,956 sq. ft. of quarantine space for the unprecedented health evaluation of all mice regardless of source; 2) 6,231 sq. ft. of additional mouse housing space; 3) 2,650 sq. ft. of procedural laboratories; 4) 4,671 sq. ft. of washing and sterilizing space; 5) a dedicated laboratory for the Mouse Models Core; 6) a mouse necropsy laboratory for the Veterinary Pathology Core; and 7) a laboratory for the In Vivo Mouse Imaging Core. A 26,341 sq. ft. interstitial deck will be constructed above the facility, which will permit service access without entering the facility proper. Central Energy Plant equipment needed to meet incremental capacities demanded by the facility will be added. The net benefit of this construction project will accrue to nationally recognized life science research at eight neighboring institutions in the Tampa Bay area. Matching funds to complete the project are provided by two of those institutions.

描述（由申请人提供）：请求支持在莫菲特塔项目新研究楼的地面上建造 29,000 平方英尺的不适宜居住的外壳空间，以建立 27,683 平方英尺的老鼠屏障设施。佛罗里达州坦帕湾中央管理的 AAALAC 认证项目的四个现有动物设施的容量已经超出，并且全部缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟议的设施将纠正动物空间的缺陷，并在严格的微生物安全环境下为功能基因组服务建立空间。它地理位置优越，靠近联邦政府资助的小鼠研究的最大焦点，并毗邻该地区最大的研究实验室空间集中地。它将建立以下内容：1）1,956平方英尺的检疫空间，用于对所有小鼠（无论其来源）进行前所未有的健康评估； 2) 6,231 平方英尺的额外鼠标容纳空间； 3) 2,650 平方英尺的程序实验室； 4) 4,671平方英尺的清洗和消毒空间； 5）小鼠模型核心的专用实验室； 6) 兽医病理学核心的小鼠尸检实验室； 7) 小鼠体内成像核心实验室。设施上方将建造一个 26,341 平方英尺的间隙甲板，无需进入设施本身即可进行服务访问。将增加满足该设施增量容量需求所需的中央能源厂设备。该建设项目的净效益将有助于坦帕湾地区八个邻近机构的国家认可的生命科学研究。其中两家机构提供了完成该项目的配套资金。