JUVENILE ONSET OCD AS A MEANINGFUL DEVELOPMENT SUBTYPE

青少年发作的强迫症是一种有意义的发展亚型

• 批准号: 6391351
• 负责人: DANIEL A GELLER
• 金额: $ 16.85万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6391351
• 关键词: Tourette's syndrome; adolescence (12-20); adult human (21+); age difference; attention deficit disorder; body physical characteristic; clinical research; comorbidity; disease /disorder classification; disease /disorder etiology; disease /disorder onset; family genetics; genetic susceptibility; human puberty; human subject; interview; longitudinal human study; mental disorder diagnosis; neuropsychology; obsessive compulsive disorder; phenotype; prognosis; psychological tests; questionnaires

This application represents an integrated plan of research and training which will allow the Candidate to acquire the necessary skills to become independent as a clinical investigator. The Candidate has demonstrated a commitment towards the pursuit of clinical excellence and original research in the area of Obsessive Compulsive Disorder (OCD) in children and adolescents over many years, manifested by a highly reputed clinical program, small grant support and original scientific publications. The Candidate is seeking the support of a Mentored Clinical Scientist Development Award in order to undertake a comprehensive program of didactic and mentored training and clinical research using the proposed research plan as a vehicle for scientific development. The Candidate is in an outstanding environment for this purpose and has assembled a highly qualified group of consultants who are leaders in their field and who are dedicated to the Candidate's research career success. The scientific development plan proposed includes training in Clinical Research Methods in Child Psychiatry-20 percent, Clinical Research Methods in Adults with Obsessive Compulsive and Related Disorders-10 percent, and courses at the Harvard School of Public Health in epidemiology and biostatistics which comprise the Formal Didactic Training-10 percent. The Candidate's background, scientific biography, research objectives and career goals reveal a clear and constant trajectory and a coherent plan for a career studying OCD in the pediatric population. The rationale for the Candidate's proposed Research Plan-35 percent, derives from the premise that OCD is very likely a heterogeneous disorder and further, that an understanding of this etiologic heterogeneity is important, not only for clinical purposes, but also as a fundamental step in future neurobiological research. The Candidate contends, using his own work and the reviewed literature, that age at onset of OCD represents the most compelling variable to study to examine etiologic heterogeneity because OCD which begins in childhood differs in important ways from the adult-onset disorder. To this end, the Candidate proposes to test several competing hypotheses to determine whether the childhood-onset form of OCD is the same or different from adult-onset OCD by studying the clinical correlates and familial aggregation of psychiatric disorders in 100 juvenile OCD probands, 50 adult OCD probands with juvenile-onset OCD and 50 adult OCD probands with adult-onset OCD and their first degree relatives. By providing data that are independent from findings in the proband, family-genetic data provide a powerful method to investigate whether juvenile-onset OCD is a clinically meaningful subtype of OCD. The clinical, scientific, and public health relevance of confirming or refuting these hypotheses is discussed.

该申请代表了一个综合的研究和培训计划，将使候选人获得必要的技能，成为独立的临床研究者。 候选人多年来一直致力于在儿童和青少年强迫症 (OCD) 领域追求临床卓越和原创研究，这通过享有盛誉的临床项目、小额赠款支持和原创科学出版物得到体现。 候选人正在寻求指导临床科学家发展奖的支持，以便利用拟议的研究计划作为科学发展的工具，开展教学和指导培训以及临床研究的综合计划。为此，候选人处于一个优越的环境中，并组建了一支高素质的顾问团队，他们是各自领域的领导者，致力于候选人研究事业的成功。 拟议的科学发展计划包括儿童精神病学临床研究方法培训（20%）、强迫症及相关疾病成人临床研究方法培训（10%）以及哈佛大学公共卫生学院流行病学和生物统计学课程，其中包括正式课程教学培训 - 10%。 候选人的背景、科学传记、研究目标和职业目标揭示了研究儿科强迫症的清晰且持续的轨迹和连贯的职业计划。候选人提出的研究计划 35% 的基本原理源自这样一个前提：强迫症很可能是一种异质性疾病，而且进一步了解这种病因异质性很重要，不仅出于临床目的，而且作为研究的基本步骤。未来的神经生物学研究。 候选人利用他自己的工作和审阅的文献认为，强迫症发病年龄是研究病因异质性最引人注目的变量，因为从儿童时期开始的强迫症与成人发病的疾病在许多重要方面有所不同。 为此，候选人建议通过研究 100 名青少年强迫症先证者的精神疾病的临床相关性和家族聚集性来检验几个相互竞争的假设，以确定儿童期发病的强迫症形式​​与成人发病的强迫症是否相同或不同。患有青少年发病的强迫症的成年强迫症先证者和 50 名患有成年发病的强迫症的成年强迫症先证者及其一级亲属。 通过提供独立于先证者发现的数据，家族遗传数据提供了一种强有力的方法来研究青少年发病的强迫症是否是有临床意义的强迫症亚型。 讨论了证实或反驳这些假设的临床、科学和公共卫生相关性。