CONQUERING LYMPHATIC DISEASE--SETTING THE RESEARCH AGEND

战胜淋巴疾病——设定研究议程

• 批准号: 6084729
• 负责人: MARLYS Hearst WITTE
• 金额: $ 3.4万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-11 至 2002-05-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6084729
• 关键词: angiogenesis; developmental immunology; immunogenetics; immunopharmacology; lymphatic system; lymphedema; meeting /conference /symposium; travel

The Conquering Lymphatic Disease: Setting the Research Agenda conference series is a structured "think tank" approach to collaborative research needed for significant progress in understanding a long-neglected major body system and the spectrum of its disorders. Three conferences are planned: 1) Year 1- Lymphatic Vascular Biology and Lymphedema-Angiodysplasia Syndromes will engage scientists from around the world in exploring and characterizing the state-of-the-art and key unknowns with respect to lymphatic genetics and development, lymphatic physiology and pharmacology, imaging lymphatic structures, and angiogenesis and their implications in the clinical management of lymphatic disorders and cancer; 2) Year 3- The Lymphatic Apparatus as an Integrated/Integrative System will foster adoption of varied basic and clinical research approaches that put the lymphatic system in perspective with regard to other body systems and its impact on the person; 3) Year 5-Building the Collaborative Lymphatic Community will focus on an action plan for bringing dispersed investigational efforts together around coordinated developmental, structural, functional, and restorative studies that make the most effective and efficient use of resources in yielding the research outcomes likely to result in clinical breakthroughs that ameliorate the devastating impact that lymphatic disease has on many millions of individuals and families worldwide. In project years two and four, conference momentum will be enhanced through networking among participants in the first invitational conference, as well as with an enlarging cadre of researchers, clinicians, and patient groups identified over the project period. Coordinating activities will focus on effective use of the Internet through a project Website-CollaboLymph-involving The University of Arizona, Stanford University, Lymphatic Research Foundation, and others. Growing understanding of the lymphatic system's role in overall health and in a broad array of diseases and disabling conditions, including circulatory disorders, cancer, infectious, gastrointestinal, pulmonary and skin diseases, and immunologic and rare genetic disorders, provides the rationale for engaging a number of NIH entities in the project. Thus, the think tank process is expected to bring thoughts into action and to accelerate research findings into improved understanding and enhanced clinical management of lymphatic system disorders.

征服淋巴疾病：制定研究议程系列会议是一种结构化的“智库”合作研究方法，需要在了解长期被忽视的主要身体系统及其疾病谱方面取得重大进展。 计划举行三场会议： 1) 第一年——淋巴血管生物学和淋巴水肿-血管发育不良综合征将吸引来自世界各地的科学家探索和描述淋巴遗传学和发育、淋巴生理学方面的最新技术和关键未知因素药理学、淋巴结构成像、血管生成及其对淋巴疾病和癌症临床治疗的影响； 2) 第三年——淋巴器官作为一个综合/综合系统将促进各种基础和临床研究方法的采用，这些方法将淋巴系统与其他身体系统及其对人体的影响结合起来； 3) 第 5 年——建立协作性淋巴社区将重点关注一项行动计划，将分散的研究工作围绕协调发展、结构、功能和恢复性研究汇集在一起​​，从而最有效和高效地利用资源，产生可能的研究成果带来临床突破，减轻淋巴疾病对全世界数百万个人和家庭的破坏性影响。 在项目第二年和第四年，将通过第一次邀请会议参与者之间的网络以及项目期间确定的不断扩大的研究人员、临床医生和患者群体骨干队伍来增强会议势头。 协调活动将侧重于通过一个项目 Website-CollaboLymph 有效利用互联网，该项目涉及亚利桑那大学、斯坦福大学、淋巴研究基金会等。人们越来越了解淋巴系统在整体健康以及多种疾病和残疾状况中的作用，包括循环系统疾病、癌症、传染病、胃肠道、肺部和皮肤疾病以及免疫和罕见遗传性疾病，这为参与许多研究提供了理由。项目中 NIH 实体的数量。 因此，智库过程预计将把想法付诸行动，并加速研究成果，以提高对淋巴系统疾病的理解和加强临床管理。