SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM

免疫系统中的信号转导

• 批准号: 6189448
• 负责人: Christopher E. Rudd
• 金额: $ 0.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6189448
• 关键词: biological signal transduction; immune system; meeting /conference /symposium; travel

DESCRIPTION (Applicant's Description) This application seeks partial funding for a Summer Conference on "Signal Transduction in the Immune System" to be held from July 8-13 in Saxton's River, Vermont. The major goal of the conference is to provide a comprehensive focus on recent advances in the knowledge of signaling mechanisms of immune cells. An understanding of signal transduction pathways is central to an understanding of the molecular basis of various immune functions involved in combating cancer and opportunistic infections. Dysregulation of signaling pathways almost certainly also accounts for the appearance of various leukemias and lymphomas. Widespread interest of immune cell signaling exists in universities, research institutes and biotechnology. However, signal transduction at immunology meetings is generally covered as an adjunct subject, with little detailed coverage. An annual meeting with an in- depth focus on the details of signal transduction in the immune system has been missing. "Signal Transduction in the Immune System" is proposed as a means to fill this gap by covering a spectrum of topics from tyrosine, serine and lipid kinases to adaptor proteins (SLP-76, LAT, FYB/SLAP, 3BP-2 etc.) to signaling in thymic differentiation and in response to cytokines. There will be three main objectives of this conference: (1) To provide a critical and intensive overview of the current status of signaling proteins that control of various immune functions. Our meeting will cover a full-range of topics from an in depth analysis of specific signaling molecules and networks to the application of this knowledge to immunobiology. (2) To bring together senior scientists and young investigators in a convivial atmosphere of presentations and informal discussions. It is hoped that this environment will help develop the investigative skills and enthusiasm of students and young investigators by interacting with established investigators. (3) To begin an annual forum for investigators interested in a comprehensive focus on signaling events in the immune system.

描述（申请人的描述） 本申请为“信号”夏季会议寻求部分资金 免疫系统转导”将于 7 月 8 日至 13 日在萨克斯顿举行 河，佛蒙特州。 会议的主要目标是提供一个 全面关注信号知识的最新进展 免疫细胞的机制。 了解信号转导途径 对于理解各种免疫的分子基础至关重要 参与对抗癌症和机会性感染的功能。 信号通路的失调几乎肯定也是导致 各种白血病和淋巴瘤的出现。 免疫的广泛兴趣 细胞信号传导存在于大学、研究机构和生物技术领域。 然而，免疫学会议上的信号转导通常被视为 附属主题，几乎没有详细的报道。 与内部人士举行的年度会议 深度关注免疫系统中信号转导的细节 失踪了。 “免疫系统中的信号转导”被提议为 意味着通过涵盖酪氨酸、丝氨酸等一系列主题来填补这一空白 和脂质激酶与接头蛋白（SLP-76、LAT、FYB/SLAP、3BP-2 等） 胸腺分化和细胞因子反应中的信号传导。 本次会议将有三个主要目标： (1) 对当前的状况进行批判性和深入的概述 控制各种免疫功能的信号蛋白。 我们的会议将 通过对特定信号的深入分析涵盖全方位的主题 分子和网络将这些知识应用于免疫生物学。 （2）将资深科学家和年轻研究者聚集在一起 演示和非正式讨论的气氛。 希望这 环境将有助于培养调查技能和热情 学生和年轻研究者通过与既定的人互动 调查人员。 (3) 为对综合性研究感兴趣的研究者举办年度论坛 重点关注免疫系统中的信号事件。