PRODUCTION SEQUENCING OF DROSOPHILA GENOME

果蝇基因组的生产测序

• 批准号: 6302072
• 负责人: MICHAEL J PALAZZOLO
• 金额: $ 148.12万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302072
• 关键词: Drosophilidae; biomedical automation; biotechnology; computer assisted sequence analysis; genetic mapping; genome; health science manpower; health science profession; job performance; nucleic acid sequence; polymerase chain reaction; robotics

This proposal requests funding to expand the effort dedicated to sequencing the Drosophila genome. The ambitious scale-up is part of our plan to complete the sequence of the 120 megabases of the euchromatic genome of this central model organism shortly after the turn of the century. It is expected that the increase in sequencing production will come from both the additional number of people working on the project and from a steadily increasing sequencing efficiency. The increased efficiency will be achieved largely through the interdisciplinary interaction of the biology, automation, and computation groups at LBL. This section of the proposal describes the directed strategy that is being used, the current status of the automation and computation efforts, the manner in which the workforce is organized, and the costs associated with the production effort.

该提案要求资金扩大专门用于测序的努力 果蝇基因组。 雄心勃勃的规模是我们计划的一部分 填写整体基因组的120兆瓦的序列 这个世纪之交后不久，这种中央模型有机体。 这是 预计测序生产的增加将来自 其他从事该项目的人以及稳定的 提高测序效率。 提高的效率将是 在很大程度上通过生物学的跨学科相互作用来实现 自动化和LBL的计算组。 提案的这一部分 描述正在使用的定向策略，当前状态 自动化和计算工作，劳动力的方式 是有组织的，以及与生产工作相关的成本。