C-H Bond Activation in Synthesis of Organic Molecules

有机分子合成中的 C-H 键活化

• 批准号: 6326740
• 负责人: DALIBOR SAMES
• 金额: $ 23.73万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326740
• 关键词: alkaloids; alkyl group; aspidosperma alkaloid; biological products; catalyst; chemical bond; chemical synthesis; imines; metal complex; stereochemistry; terpenes

DESCRIPTION: (Applicant's Description) The proposed program focuses on synthesis of complex natural products via C-H bond activation. The possibility of site selectivity of these transformations in the context of complex substrates is of significant synthetic potential. Assuming such goals were realized novel and unique synthetic strategies for the assembly of natural products can be envisioned. This program will focus on development of transition metal reagents and catalysts for directed C-H activation. Selectivity of C-H activation reactions will be achieved through the use of a suitable heteroatom/functionality (imine group in most cases) to activate and direct metal complexes to geminal dialkyl groups. Following this logic, new ways to quaternary stereogenic centers will be explored in the context of three classes of natural products (aspidosperma alkaloids, teleocidin alkaloids and selected terpene-derived natural products).

描述：（申请人的描述）拟议的计划侧重于 通过C-H键活化合成复杂的天然产物。可能性 在复杂的背景下这些转化的位点选择性 底物具有重要的合成潜力。假设这样的目标是 实现了用于天然产物组装的新颖且独特的合成策略 产品是可以想象的。该计划将重点发展 用于定向 C-H 活化的过渡金属试剂和催化剂。 C-H活化反应的选择性将通过使用 合适的杂原子/官能团（大多数情况下是亚胺基）来激活和 将金属配合物直接连接至偕二烷基。按照这个逻辑，新 将在三个背景下探索第四纪立体中心的方法 天然产物类别（蜘蛛子生物碱、teleocidin 生物碱和 精选的萜烯衍生天然产物）。