TREATMENT OF BRAIN TUMORS WITH 2-5A-ANTITELOMERASE RNA

用 2-5A-抗端粒酶 RNA 治疗脑肿瘤

• 批准号: 6342144
• 负责人: SEIJI KONDO
• 金额: $ 24.75万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342144
• 关键词: DNA replication; antisense nucleic acid; apoptosis; athymic mouse; cis platinum compound; combination cancer therapy; complementary RNA; cyclin dependent kinase; cytotoxicity; disease /disorder model; drug screening /evaluation; endoribonucleases; enzyme activity; enzyme inhibitors; gene targeting; glioma; histopathology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplastic cell; nonhuman therapy evaluation; oligonucleotides; pharmacokinetics; telomerase; tissue /cell culture

项目成果

2-5A antisense telomerase RNA therapy for intracranial malignant gliomas.

2-5A反义端粒酶RNA治疗颅内恶性神经胶质瘤。

• 发表时间: 2000
• 期刊: Cancer research.
• 作者: Mukai,S;Kondo,Y;Koga,S;Komata,T;Barna,BP;Kondo,S
• 通讯作者: Kondo,S

Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas.

抗端粒酶 RNA 2-5A 反义和顺铂联合治疗恶性胶质瘤。

• DOI: 10.3892/ijo.18.6.1287
• 发表时间: 2001
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Kondo,Y;Komata,T;Kondo,S
• 通讯作者: Kondo,S

Down-regulation of telomerase activity in malignant glioma cells by p27KIP1.

p27KIP1 下调恶性胶质瘤细胞中的端粒酶活性。

• 发表时间: 2003
• 期刊: International journal of oncology.
• 作者: Kanzawa,Takao;Komata,Tadashi;Kyo,Satoru;Germano,IsabelleM;Kondo,Yasuko;Kondo,Seiji
• 通讯作者: Kondo,Seiji