CORE--PATHOPHYSIOLOGY LABORATORY

核心--病理生理学实验室

• 批准号: 6318409
• 负责人: WILFORD VAN GORP
• 金额: $ 16.26万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6318409
• 关键词: biomedical facility; brain imaging /visualization /scanning; clinical research; cognition; dementia; evoked potentials; frontal lobe /cortex; human old age (65+); human subject; magnetic resonance imaging; major depression; memory disorders; neuroanatomy; neuropsychological tests; neuropsychology; pathologic process; positron emission tomography; training

The Pathophysiology Core (PA Core) has evolved from the Neuropsychology Core as a consequence of CRC findings of the previous funding period. We have identified evidence of at least two clinically and biologically meaningful subgroups of geriatric depression: 1. A group with predominant frontal systems impairment which is characterized by a distinct clinical presentation and a chronic course; and 2. A group with predominant memory impairment which is responsive to antidepressant treatment but at high risk for dementia (Alzheimer's or vascular). We argue that these subtypes are relevant to the pathophysiology of geriatric depression rather than randomly occurring comorbid states. The mission of the PA Core is to orchestrate for the CRC a program of targeted investigations into the above hypothesis using the science and techniques of four specialized laboratories: 1. neuropsychology; 2. evoked potentials; 3. structural MR neuroimaging; and 4. functional neuroimaging. Conceptual and operational integration of these laboratories provides a coordinated plan using complementary techniques to pursue biological hypothesis in a way that would be difficult, if not impossible to do, outside a CRC environment. Finally, the shared scientific goal of the PA Core provides its laboratories a coherent strategy for development of investigative methodology so that they can continue to make essential contributions to the pathophysiology of geriatric mood disorders. The findings and assessments of the PA Core will be sued by other Cores of the CRC in hypotheses examining heterogeneity in outcomes, mechanisms, and treatment of geriatric mood disorders. To accomplish its mission, the PA Core takes advantages of a unique geriatric population with a wide range of cognitive and medical morbidity necessary for testing the CRC hypotheses. Moreover, the PA Core draws upon the expertise and measures of other CRC Cores, such as Chronobiology, Psychopharmacology, and Psychosocial, to widen its scope. The PA Core will remain a central training resource in biological theory and techniques for senior and junior investigators of the CRC and for the research training programs of the Department of Psychiatry and the Medical College, including an NIMH research fellowship in geriatric mood disorders.

病理生理学核心（PA Core）是从神经心理学发展而来的 核心是 CRC 上一资助期调查结果的结果。我们 已经确定了至少两个临床和生物学证据 老年抑郁症的有意义的亚组： 1. 以 额叶系统损伤的特点是具有独特的临床特征 表现和慢性病程； 2. 记忆力较强的一组 抗抑郁治疗有反应但程度较高的损伤 痴呆症（阿尔茨海默氏症或血管性痴呆）的风险。我们认为这些亚型 与老年抑郁症的病理生理学相关，而不是 随机发生的共病状态。 PA 核心的使命是为 CRC 精心策划一项计划 利用科学和技术对上述假设进行有针对性的调查 四个专业实验室的技术： 1. 神经心理学； 2. 诱发 潜力； 3.结构MR神经影像； 4. 功能性神经影像学。 这些实验室的概念和操作整合提供了 使用互补技术的协调计划来追求生物 以一种很难甚至不可能做到的方式进行假设 在 CRC 环境之外。最后，PA 的共同科学目标 Core为其实验室提供了一个连贯的发展战略 调查方法，以便他们能够继续做出必要的 对老年情绪障碍病理生理学的贡献。这 PA 核心的调查结果和评估将被 PA 核心的其他核心起诉 CRC 的假设检验结果、机制和方法的异质性 治疗老年情绪障碍。 为了完成其使命，PA 核心利用了独特的优势 具有广泛认知和医学发病率的老年人群 检验 CRC 假设所必需的。此外，PA 核心利用 其他 CRC 核心的专业知识和措施，例如时间生物学、 精神药理学和心理社会学，以扩大其范围。 PA 核心仍将是生物理论的核心培训资源 CRC 高级和初级研究人员的技术和技术 精神病学和医学系的研究培训计划 学院，包括 NIMH 老年情绪研究奖学金 失调。