CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE

免疫衰老中的细胞周期和凋亡基因

• 批准号: 6341521
• 负责人: Argyrios N Theofilopoulos
• 金额: $ 30.21万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6341521
• 关键词: RNase protection assay; T lymphocyte; aging; apoptosis; cell cycle; cyclins; enzyme inhibitors; genetically modified animals; immunologic memory; immunosenescence; laboratory mouse; protein kinase; tissue /cell culture

DESCRIPTION (Adapted from the Investigator's abstract): This application is based on the hypothesis that immunologic senescence of T-cells is the results of two concurrent and interrelated events. The T-cell repertoire is reshaped by an expanded memory lymphocyte pool. The memory T-cells themselves reach a refractory (anergic) state manifested by further resistance to further activation, cell cycle entry and apoptosis. The first effect is attributed to the dilution of naive cells by the accumulated memory phenotype cells that leads to overall repertoire constrictions. The second effect is attributed to a generational clock that records an allocated number of activations and cell divisions by memory T-cells before promoting replicative senescence primarily by the buildup of cyclin kinase inhibitors. These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence.

描述（改编自研究者的摘要）：该应用程序是 基于以下假设：T 细胞的免疫衰老是 两个同时发生且相互关联的事件的结果。 T 细胞的全部功能是 通过扩大的记忆淋巴细胞池进行重塑。 记忆T细胞 自身达到难治（无能）状态，表现为进一步 对进一步激活、细胞周期进入和细胞凋亡的抵抗。 第一个 效应归因于初始细胞被累积的稀释 导致整体库收缩的记忆表型细胞。 这 第二个效应归因于记录了 记忆T细胞之前分配的激活和细胞分裂次数 主要通过细胞周期蛋白激酶的积累促进复制衰老 抑制剂。 这些对衰老 T 细胞的细胞周期和凋亡的研究将 有助于定义与相关的分子缺陷 免疫性衰老。