EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGING

正常衰老过程中心血管风险的演变

• 批准号: 6372298
• 负责人: GERALD Sanders BERENSON
• 金额: $ 71.34万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6372298
• 关键词: African American; aging; blood chemistry; blood glucose; blood lipid; blood pressure; body physical activity; cardiovascular disorder; cardiovascular disorder epidemiology; caucasian American; clinical research; disease /disorder proneness /risk; family genetics; gender difference; health behavior; heart function; human subject; longitudinal human study; nutrient intake activity; obesity; pathologic process; racial /ethnic difference; ultrasound blood flow measurement

DESCRIPTION (Adapted from the Applicant's Abstract): The cardiovascular (C-V) system is one of the organ systems most affected by the aging process. Significant differences in C-V morbidity and mortality occur by race and gender that influence longevity. The proposed research involves a biracial (black-white) population that has been followed for C-V risk factors and lifestyles in the Bogalusa Heart Study over the past 25 years. The specific aim of the research is to characterize traits (intrinsic aging vs. The risk factor burden) in a population reaching middle age that influence the subclinical C-V disease process in normal aging. The extensive data base collected since childhood provides information related to silent underlying C-V disease and aging. The study cohort includes 1,200 individuals born between 1959 and 1969, who were examined at least four times since childhood. The cohort will be examined for: 1) C-V risk factor variables comprising obesity measures, blood pressure, lipids, lipoproteins, apoliproproteins, homocysteine, glucose, insulin, fibrinogen, plasminogen activator inhibitor 1, intercellular adhesion molecules -1, C-reactive protein, lipid peroxides and microalbuminuria; 2) lifestyle and psychosocial variables such as tobacco and alcohol use, physical activity, diet, and life change events; 3) subclinical changes of the heart and vasculature (outcome variables) observed by echo-Doppler measurements of cardiac-carotid structure and function and brachial and radial artery compliance; and 4) selected longevity-associated allele markers, like apoE. These variables (except for the allele markers) will be measured at two points in time, with a 3-year interval. In addition, a family history of longevity and health history information on study subjects and their parents and grandparents will be obtained to evaluate familial risk characteristics of the cohort. The proposed studies will provide insights into the interaction of normal aging and predisposing factors that influence the subclinical C-V disease process in a black-white population reaching middle age. Understanding the evolution of C-V risk in normal aging can lead to more rational programs for successful aging and longevity and C-V disease prevention.

描述（改编自申请人的摘要）：心血管（C-V） 系统是受衰老过程影响最大的器官系统之一。 种族和性别发生C-V发病率和死亡率的显着差异 那会影响寿命。拟议的研究涉及混血儿 C-V风险因素遵循的（黑白）人口 在过去25年中，Bogalusa心脏研究中的生活方式。具体目标 该研究的特征是特征（内在的老化与风险因素 负担）在达到中年的人口中影响亚临床C-V 正常衰老的疾病过程。自从收集的广泛数据库以来 童年提供与无声基础C-V疾病有关的信息， 老化。该研究队列包括1959年至1969年之间出生的1200个人 从小就被检查至少四次。队列将是 检查的：1）C-V风险因素变量包括肥胖指标，血液 压力，脂质，脂蛋白，载脂蛋白，同型半胱氨酸，葡萄糖， 胰岛素，纤维蛋白原，纤溶酶原激活剂1，细胞间粘附 分子-1，C反应蛋白，脂质过氧化物和微量白蛋白尿； 2） 生活方式和社会心理变量，例如烟草和酒精，物理 活动，饮食和生活改变事件； 3）心脏和心脏的亚临床变化 脉管系统（结果变量）通过回声多普勒测量值观察到 心脏 - 偶然结构和功能以及肱和径向动脉 遵守; 4）选择寿命相关的等位基因标记，例如Apoe。 这些变量（等位基因标记除外）将在两个点测量 及时，间隔3年。此外，还有长寿的家族史和 有关研究学科及其父母和祖父母的健康史信息 将获得评估队列的家族风险特征。这 拟议的研究将提供有关正常衰老和的相互作用的见解 在A中影响亚临床C-V疾病过程的诱发因素 黑白人口达到中年。了解C-V的演变 正常衰老的风险可能会导致成功衰老的更多理性计划 和寿命和C-V疾病预防。