EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGING

正常衰老过程中心血管风险的演变

• 批准号: 6372298
• 负责人: GERALD Sanders BERENSON
• 金额: $ 71.34万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6372298
• 关键词: African American; aging; blood chemistry; blood glucose; blood lipid; blood pressure; body physical activity; cardiovascular disorder; cardiovascular disorder epidemiology; caucasian American; clinical research; disease /disorder proneness /risk; family genetics; gender difference; health behavior; heart function; human subject; longitudinal human study; nutrient intake activity; obesity; pathologic process; racial /ethnic difference; ultrasound blood flow measurement

DESCRIPTION (Adapted from the Applicant's Abstract): The cardiovascular (C-V) system is one of the organ systems most affected by the aging process. Significant differences in C-V morbidity and mortality occur by race and gender that influence longevity. The proposed research involves a biracial (black-white) population that has been followed for C-V risk factors and lifestyles in the Bogalusa Heart Study over the past 25 years. The specific aim of the research is to characterize traits (intrinsic aging vs. The risk factor burden) in a population reaching middle age that influence the subclinical C-V disease process in normal aging. The extensive data base collected since childhood provides information related to silent underlying C-V disease and aging. The study cohort includes 1,200 individuals born between 1959 and 1969, who were examined at least four times since childhood. The cohort will be examined for: 1) C-V risk factor variables comprising obesity measures, blood pressure, lipids, lipoproteins, apoliproproteins, homocysteine, glucose, insulin, fibrinogen, plasminogen activator inhibitor 1, intercellular adhesion molecules -1, C-reactive protein, lipid peroxides and microalbuminuria; 2) lifestyle and psychosocial variables such as tobacco and alcohol use, physical activity, diet, and life change events; 3) subclinical changes of the heart and vasculature (outcome variables) observed by echo-Doppler measurements of cardiac-carotid structure and function and brachial and radial artery compliance; and 4) selected longevity-associated allele markers, like apoE. These variables (except for the allele markers) will be measured at two points in time, with a 3-year interval. In addition, a family history of longevity and health history information on study subjects and their parents and grandparents will be obtained to evaluate familial risk characteristics of the cohort. The proposed studies will provide insights into the interaction of normal aging and predisposing factors that influence the subclinical C-V disease process in a black-white population reaching middle age. Understanding the evolution of C-V risk in normal aging can lead to more rational programs for successful aging and longevity and C-V disease prevention.

描述（改编自申请人的摘要）：心血管（C-V） 系统是受衰老过程影响最严重的器官系统之一。 不同种族和性别的 C-V 发病率和死亡率存在显着差异 从而影响寿命。拟议的研究涉及混血儿 已跟踪 C-V 风险因素的（黑人-白人）人群以及 Bogalusa 心脏研究过去 25 年的生活方式。具体目标 研究的重点是描述特征（内在衰老与风险因素） 负担）在中年人群中影响亚临床 C-V 正常衰老过程中的疾病过程。自此以来收集的广泛数据库 童年时期提供了与隐性潜在 C-V 疾病相关的信息 老化。该研究队列包括 1,200 名出生于 1959 年至 1969 年间的人， 自童年起至少接受过四次检查。该队列将是 检查：1) C-V 危险因素变量，包括肥胖指标、血液 压力、脂质、脂蛋白、载脂蛋白、同型半胱氨酸、葡萄糖、 胰岛素、纤维蛋白原、纤溶酶原激活剂抑制剂1、细胞间粘附 分子-1、C反应蛋白、脂质过氧化物和微量白蛋白尿； 2） 生活方式和心理社会变量，例如吸烟和饮酒、身体状况 活动、饮食和生活变化事件； 3）心脏的亚临床变化 通过回波多普勒测量观察到的脉管系统（结果变量） 心脏-颈动脉的结构和功能以及肱动脉和桡动脉 遵守; 4) 选择与长寿相关的等位基因标记，如 apoE。 这些变量（等位基因标记除外）将在两个点进行测量 及时，间隔3年。此外，还有长寿家族史和 研究对象及其父母和祖父母的健康史信息 将获得用于评估队列的家族风险特征。这 拟议的研究将深入了解正常衰老和衰老之间的相互作用 影响亚临床 C-V 疾病过程的诱发因素 黑人白人人口步入中年。了解 C-V 的演变 正常老龄化中的风险可以导致更合理的成功老龄化计划 以及长寿和 C-V 疾病预防。