Linear Geiger Mode Detector Technology for Time Resolved Spectral Measurements

用于时间分辨光谱测量的线性盖革模式检测器技术

• 批准号: ST/N000129/1
• 负责人: Jonathan Lapington
• 金额: $ 18.67万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FN000129%2F1
• 关键词: Linear; Geiger; Mode; Detector; Technology

The primary objective of this project is to develop an new class of detection system for cost effective time-resolved photon counting spectral measurement, initially aimed at time-resolved Raman spectroscopy (TRRS). TRRS is an established method to remove the delayed fluorescence signal from the prompt Raman photons, particularly for organic samples where the fluorescence signal is often much larger. Though very powerful as a sample analysis technique, TRRS has had limited uptake due to cost and complexity. Currently available TRRS systems separate the Raman and fluorescence signals by using either a gated Intensified CCD, or by using fast optical gating technology. Both approaches are complex, expensive and restricted to laboratory environments. This proposal aims to produce a new, smaller, cheaper class of detection system for TRRS and other time-resolved spectral measurements by integrating a SPAD linear array developed by the University of Sheffield with the fast readout electronics developed by the University of Leicester. Instead of gating, this system will provide the necessary time differentiation of Raman and fluorescence signals by photon time stamping.Such an instrument is expected to open up new commercial applications in to fields ranging from security applications such as identification of counterfeit materials and pharmaceutical quality control, to biological applications including protein manufacture and potentially identification of cancer markers. A cost effective time-resolved Raman instrument would be disruptive technology with beneficiaries ranging from the project partners through commercial profit and licensing, suppliers of key components including commercial detector and high rep rate lasers from UK and European companies. Potential end-user beneficiaries include drug companies and their customers, the security services and general public through improved detection of hazardous and illegal materials, and public well-being through possible advances in cancer detection.The detector system is also potentially game-changing for a number of other commercial applications. These include: LIDAR for 3D imaging and environmental monitoring; fluorescence lifetime imaging and related technologies for biological research, drug discovery and clinical diagnostics; and trace gas analysis using cavity enhanced absorption spectroscopy for pollution monitoring and medical diagnostics.The project work is based on previous STFC-funded research into detectors and electronics at the Universities of Leicester and Sheffield and at CERN.The Department of Electronic & Electrical Engineering at the University of Sheffield has been carrying out research into SPADs for over 15 years. Recent knowledge exchange activities include IR APD linear array with LIDAR Technology, X-ray APDs with University of Leicester, photodiodes/APDs for radiation thermometry with LAND Instrument International Ltd, and IR APD with Lasertel.Previous STFC support has funded the PI, Lapington, to develop very high time resolution pixellated microchannel plate photomultiplier systems for commercial applications in the life science arena, based on a modular, multichannel high speed electronics with picosecond event timing resolution developed in collaboration with CERN. The electronics utilise two very high speed CERN-designed ASICs developed for the LHC-ALICE experiment in a modular design allowing systems with up to 1024 channels.The University of Leicester and commercial partner, IS-Instruments, were recently awarded a TSB-funded "Emerging Imaging Technologies" feasibility study for preliminary investigation of this new technique for TRRS. This new project will move the technology from proof of concept to a commercial prototype for TRRS which will allow IS-Instruments to commercialise a new suite of spectrometer systems capable of separating signals in time, generating the potential for cost effective, hand-held TRRS spectrometer.

该项目的主要目的是开发一种新的检测系统，用于成本有效的时间分辨光子计数频谱测量，最初针对时间分辨的拉曼光谱（TRRS）。 TRR是一种从迅速拉曼光子中去除延迟荧光信号的已建立方法，特别是对于荧光信号通常更大的有机样品。尽管作为样本分析技术非常强大，但由于成本和复杂性，TRR的吸收率有限。当前可用的TRRS系统通过使用封闭式加强的CCD或使用快速的光学门控技术将拉曼和荧光信号分开。两种方法都是复杂，昂贵的，并且仅限于实验室环境。该提案旨在通过整合由谢菲尔德大学开发的SPAD线性阵列与莱斯特大学开发的快速读取电子设备，为TRR和其他时间分辨的光谱测量结果生产出新的，更小，更便宜的检测系统。该系统将通过光子时间冲压提供必要的时间差异，而不是进行门控。一种经济有效的时间解决的拉曼工具将是破坏性的技术，受益人从项目合作伙伴到商业利润和许可，包括商业探测器和英国和欧洲公司的高代价激光器在内的关键组件的供应商，包括商业利润和许可。潜在的最终用户受益人包括制药公司及其客户，通过改善危险和非法材料的检测，安全服务和公众，以及通过癌症检测的可能进展，公众福祉。检测器系统也有可能改变许多其他商业应用。其中包括：用于3D成像和环境监测的LIDAR；用于生物学研究，药物发现和临床诊断的荧光寿命成像和相关技术；使用空腔增强吸收光谱的痕量气体分析，以进行污染监测和医学诊断。该项目工作基于莱斯特大学和谢菲尔德大学以及Sheffield大学以及Sheffield大学的探测器和电子产品的先前研究。 Recent knowledge exchange activities include IR APD linear array with LIDAR Technology, X-ray APDs with University of Leicester, photodiodes/APDs for radiation thermometry with LAND Instrument International Ltd, and IR APD with Lasertel.Previous STFC support has funded the PI, Lapington, to develop very high time resolution pixellated microchannel plate photomultiplier systems for commercial applications in the life science arena, based on与CERN合作开发了具有Picsecond事件时正时分辨率的模块化多通道高速电子设备。该电子设备利用了为LHC-Alice实验开发的两个非常高速的CERN设计的ASIC，在模块化设计中允许具有多达1024个渠道的系统。莱斯特大学和商业合作伙伴Is-Insplormess最近获得了TSB资助的“由TSB资助的”“新兴成像技术”的“新兴成像”研究，用于新的技术，用于新的技术。这个新项目将把技术从概念验证转变为TRR的商业原型，该原型将使Is-Insploments能够将能够及时分开信号的新型光谱仪系统商业化，从而产生具有成本效益的手持TRR Spectrrs光谱仪的潜力。

项目成果

Investigating microchannel plate PMTs with TOFPET2 multichannel picosecond timing electronics

使用 TOFPET2 多通道皮秒计时电子器件研究微通道板 PMT

• DOI: 10.1016/j.nima.2019.162758
• 发表时间: 2020
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Lapington J

Picosecond imaging at high spatial resolution using TOFPET2 AISC v2d and microchannel plate detector

使用 TOFPET2 AISC v2d 和微通道板探测器进行高空间分辨率皮秒成像

• DOI: 10.1088/1748-0221/17/09/c09016
• 发表时间: 2022
• 期刊: Journal of Instrumentation
• 影响因子: 1.3
• 作者: Sudjai T

Operation of microchannel plate PMTs with TOFPET multichannel timing electronics

• DOI: 10.1016/j.nima.2018.10.132
• 发表时间: 2019-08
• 期刊: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: S. Leach;J. Lapington;J. Milnes;T. Conneely;R. Bugalho;S. Tavernier