DRUG TARGETING TO HIV INFECTED CELLS

针对 HIV 感染细胞的药物

• 批准号: 6308873
• 负责人: NEJAT A DUZGUNES
• 金额: $ 0.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308873
• 关键词: AIDS; bacteria; biological products; biomedical resource; drug /agent; immunology; infection; inflammation; lymphatic system; spectrometry; structural biology; virus

We are developing methods to deliver antiviral agents to HIV-infected cells, and synthesizing new antiviral agents that may prevent the entry of HIV into host cells. We have synthesized novel lipophilic derivatives of cyclodextrin sulfate which cannot only be inserted intoliposomes, but also serve as antiviral agents themselves and enable solubiligation of non-water-soluble drugs. We are requesting the use of the Facility to analyze these new compounds.

我们正在开发向患者提供抗病毒药物的方法 HIV感染的细胞，并合成新的抗病毒药物 防止艾滋病毒进入宿主细胞。 我们合成了小说 硫酸环糊精的亲脂性衍生物，不仅可以 插入脂质体中，但本身也可用作抗病毒剂 并能够溶解非水溶性药物。 我们是 请求使用该设施来分析这些新化合物。