1H NMR OF MUSCLE TRIGLYCERIDE & ITS RELATIONSHIP TO INSULIN RESISTANCE

肌肉甘油三酯的 1H NMR

• 批准号: 6335269
• 负责人: DANIEL STEIN
• 金额: $ 1.39万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2001-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6335269
• 关键词: Mammalia; animal tissue; bioimaging /biomedical imaging; biological products; biomedical resource; growth /development; magnetic resonance imaging; neoplasm /cancer; radiology; technology /technique; Mammalia; animal tissue; bioimaging /biomedical imaging; biological products; biomedical resource; growth /development; magnetic resonance imaging; neoplasm /cancer; radiology; technology /technique

Our first generation pH indicator (6-fluoropyridoxol) has been successfully observed in vivo to detect the transmembrane pH gradient which was found to be reversed compared with normal tissue. A new analog 6-fluoropyridoxamine has been prepared with a pKa of 7.05 and its utility has been demonstrated in whole blood and the perfused heart. pH is thought to strongly influence the uptake and retention of various chemotherapeutic drugs and we have initiated studies of the pharamcokinetics of 5-fluorouracil and the pro-drug 5-fluorocytosine. pH and drug clearance may be observed simultaneously in tumors in vivo. (Service 8) REPORT PERIOD: (09/01/97-08/31/98)

我们的第一代pH指标（6-氟吡啶毒素）已经 成功观察到体内以检测跨膜pH梯度 与正常组织相比，发现这种情况是逆转的。 一个新 模拟6-氟吡啶胺的PKA为7.05，并且 它的效用已在全血和灌注中得到证明 心。 pH被认为强烈影响摄取和保留率 在各种化学治疗药物中，我们已经开始研究 5-氟尿嘧啶和亲药5-氟环胞菌素的Pharamcokinetics。 可以在肿瘤中同时观察到pH和药物清除率 体内。 （服务8）报告期限：（09/01/97-08/31/98）