CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTER

克劳德·D·佩珀美国老年人独立中心

• 批准号: 6168069
• 负责人: JEFFREY B. HALTER
• 金额: $ 142.6万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168069
• 关键词: geriatrics

This is a competing renewal application for support of the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To enhance the independence of older people by developing and testing new interventions for common health problems causing disabilities. 2) To provide Research Resources Cores that support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to loss of independence of older adults. 3) To strengthen the UM environment for training of future academic leaders in geriatrics and aging. 4) To attract UM junior faculty to research on problems that limit independence of older adults and on potential interventions to enhance such independence. 5) To carry out innovative demonstration and dissemination projects to translate OAIC research findings in order to improve the independence of older adults. The UM Pepper Center has a well established leadership and administrative structure, Research Development Core (RDC), and four Research Resources Core (Human Subjects Core; Biomechanics Core; Methodology, Data Management and Analysis Core; and Core Facility for Aged Rodents). The RDC features three central elements: (1) a Pilot/Feasibility Grants program; (2) a series of 2-3 day Research Retreats; and (3) a Mentorship Program. In addition, three Intervention Development Studies (IDSs) and a Demonstration and Information Dissemination Project (DIDP) are included in this competing renewal application. The three IDSs test intervention hypotheses regarding balance training to reduce falls, use of external aids and specific exercises to compensate for impaired sensorimotor function in elderly people with peripheral neuropathy, and the impact of modulation of body size on disease free survival in mouse models of aging. These projects have been selected to capitalize on UM's strength in development and testing of quantitative measures of functional status, expertise in geriatric pathophysiology, and experience in the use of aging animal models. The proposed IDSs will benefit greatly from the multi-disciplinary nature of the OAIC faculty. The DIDP will translate findings from IDSs and other OAIC activities to community based medical practice, using an existing network of geriatrics programs in Michigan communities which serve as model demonstration and training sites.

这是一项竞争性更新申请，旨在支持密歇根大学 (UM Pepper Center) 的 Claude D. Pepper 美国老年人独立中心 (OAIC)。 UM Pepper 中心的具体目标是： 1) 通过开发和测试针对导致残疾的常见健康问题的新干预措施来增强老年人的独立性。 2) 提供研究资源核心，支持和协助研究者发起的研究项目，这些项目可以对导致老年人丧失独立性的基本机制产生新的见解。 3) 加强澳大环境，培养未来老年医学和老龄化领域的学术领袖。 4）吸引密歇根大学的初级教师研究限制老年人独立性的问题以及增强这种独立性的潜在干预措施。 5) 开展创新示范和传播项目，转化OAIC的研究成果，以提高老年人的独立性。 UM Pepper 中心拥有完善的领导和管理结构、研究开发核心 (RDC) 和四个研究资源核心（人类受试者核心；生物力学核心；方法、数据管理和分析核心；以及老年啮齿动物核心设施）。 RDC 具有三个核心要素：(1) 试点/可行性补助计划； (2) 一系列为期2-3天的研究静修活动； (3) 导师计划。此外，这项竞争更新申请中还包括三项干预发展研究（IDS）和一个示范和信息传播项目（DIDP）。 三个 IDS 测试干预假设，涉及平衡训练以减少跌倒、使用外部辅助设备和特定练习来补偿患有周围神经病的老年人受损的感觉运动功能，以及调节体型对衰老小鼠模型无病生存的影响。选择这些项目是为了利用密歇根大学在开发和测试功能状态定量测量方面的优势、老年病理生理学方面的专业知识以及使用衰老动物模型的经验。拟议的 IDS 将从 OAIC 教师的多学科性质中受益匪浅。 DIDP 将利用密歇根社区现有的老年病学项目网络作为模型示范和培训场所，将 IDS 和其他 OAIC 活动的研究结果转化为基于社区的医疗实践。