CPDD ANTINOCICEPTION, PHYSICAL DEPENDENCE AND ABUSE

CPDD 抗伤害、身体依赖性和滥用

• 批准号: 6287132
• 负责人: LOUIS S. HARRIS
• 金额: --
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6287132
• 关键词: Primates; analgesia; analgesics; behavioral habituation /sensitization; drug abuse; drug habituation; drug screening /evaluation; drug tolerance; drug withdrawal; inhibitor /antagonist; laboratory mouse; laboratory rat; narcotic antagonists; stimulant /agonist

This represents a competitive renewal of a major portion of NIDA contract N01DA38200. The portion of N01DA38200 being renewed herein, the entire contract (NIDA contract 271-90-7200) which preceded it, and several previous contracts dating back 19 years have focused on the generation of data related to the pharmacological properties and abuse liability profiles of a large number of opioid agonist, antagonist, and mixed agonist/antagonist agents. This project represents an extension of a search for potent analgesics with reduced abuse potential. In addition, data generated by this project are part of the scientific database used in decisions pertaining to scheduling of drugs under domestic laws (Controlled Substances Act) and international treaties (Single Convention and Psychotropic Convention). In brief, the objectives of this contract are: (1) to evaluate the antinociceptive activity of test compounds in mice; (2) to evaluate the effects of test compounds in opiate-dependent rats and/or monkeys; (3) to evaluate the intrinsic physical dependence capacity of test compounds in drug-naive monkeys; add (4) to assess the reinforcing properties of test compounds in monkey self-administration studies. The anticipated end results of this contract are written reports detailing the findings.

这代表了NIDA合同的主要部分的竞争性更新 N01DA38200。 N01DA38200的部分被续订，整个 合同（NIDA合同271-90-7200） 以前可以追溯到19年的合同重点是一代 与药理特性和滥用责任有关的数据 大量阿片类药物激动剂，拮抗剂和混合物的轮廓 激动剂/拮抗剂。该项目代表了 搜索具有滥用潜力降低的有效镇痛药。此外， 该项目生成的数据是使用的科学数据库的一部分 在与国内法律计划有关的毒品方面的决定中 （受控物质法）和国际条约（单一公约 和精神惯例）。 简而言之，本合同的目标是：（1）评估 小鼠测试化合物的抗伤害感受活性； （2）评估 依赖鸦片依赖性大鼠和/或猴子中测试化合物的作用； （3） 评估测试化合物的内在物理依赖能力 在药物猴子中；添加（4）以评估 猴子自给研究中的测试化合物。预期 本合同的最终结果是详细介绍发现的书面报告。

项目成果

Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.

立体选择性 mu- 和 delta-阿片受体相关的镇痛作用并与 ( )-蒂巴因结合。

• DOI: 10.1016/s0014-2999(98)00862-0
• 发表时间: 1999
• 期刊: European journal of pharmacology
• 影响因子: 5
• 作者: Aceto,MD;Harris,LS;Abood,ME;Rice,KC
• 通讯作者: Rice,KC

Dependence studies of new compounds in the rhesus monkey, rat and mouse (1997).

新化合物在恒河猴、大鼠和小鼠中的依赖性研究（1997）。

• 发表时间: 1998
• 期刊: NIDA research monograph
• 作者: Aceto,MD;Bowman,ER;Harris,LS;May,EL
• 通讯作者: May,EL