TOXICOLOGIC & CARCINOGENIC CHEMICALS IN ANIMALS

毒理学

• 批准号: 6200810
• 负责人: JOE J PREJAEAN
• 金额: $ 72.5万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-30 至 2001-06-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6200810
• 关键词: bromine; cell proliferation; chemical carcinogen; chemical carcinogenesis; chemicals; cytotoxicity; halohydrocarbon; imidazole; laboratory mouse; laboratory rat; longitudinal animal study; oral administration; thyroid hormones; toxicant screening; uridine diphosphate

The objectives of this contract are to determine the potential toxicity and carcinogenicity of 6 chemicals via the oral route to F344 rats and B6C3F1 mice. The project involves prechronic and/or chronic studies as follows: Sodium chlorate involves 21-day and 2-year studies via dosed water. Special studies in the 21-day study include cell proliferation and clinical laboratory studies. Dibromoacetic acid involves 14-day, 90-day and 2-year studies via dosed water. Special studies in the 90-day study include cell proliferation, clinical laboratory studies, and SMVCE. MX involves 14-day, 90-day and 2-year studies via dosed water. Special studies in the 90-day study include clinical laboratory studies and SMVCE. Bromodichloromethane involves 21-day and 2-year studies via dosed water. Special studies in the 21-day study include cell proliferation and clinical laboratory studies. 2-Methylimidazole involves 2-year studies via dosed feed, with special studies including thyroid hormones and UDP-GT. 4-Methylimidazole involves 2-year studies via dosed feed, with special studies including thyroid hormones and UDP-GT.

该合同的目标是确定潜在的毒性 通过口服F344大鼠的6种化学物质的致癌性和 B6C3F1小鼠。 该项目涉及预测和/或慢性研究 以下内容： 氯酸钠涉及通过剂量水进行的21天和2年研究。 21天研究的特殊研究包括细胞增殖和 临床实验室研究。 二溴乙酸涉及14天，90天和2年的研究 水。 90天研究的特殊研究包括细胞增殖， 临床实验室研究和SMVCE。 MX涉及14天，90天和2年通过剂量水研究。 特别的 90天研究中的研究包括临床实验室研究和 SMVCE。 溴二氯甲烷涉及通过剂量水进行的21天和2年研究。 21天研究的特殊研究包括细胞增殖和 临床实验室研究。 2-甲基咪唑涉及通过剂量饲料进行的2年研究，特殊 包括甲状腺激素和UDP-GT在内的研究。 4-甲基咪唑涉及通过剂量饲料进行的2年研究，特殊 包括甲状腺激素和UDP-GT在内的研究。