CEREBROSPINAL FLUID MARKERS OF AGING AND BRAIN DISEASE

衰老和脑部疾病的脑脊液标志物

• 批准号: 6413958
• 负责人: Stanley I. Rapoport
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6413958
• 关键词: Alzheimer's disease; aging; biomarker; brain disorder diagnosis; cerebrospinal fluid; clinical research; cytokine receptors; diagnosis design /evaluation; enzyme linked immunosorbent assay; human old age (65+); human subject; interleukin 6; major depression; mental disorder diagnosis; neurofibrillary tangles; tau proteins; Alzheimer's disease; aging; biomarker; brain disorder diagnosis; cerebrospinal fluid; clinical research; cytokine receptors; diagnosis design /evaluation; enzyme linked immunosorbent assay; human old age (65+); human subject; interleukin 6; major depression; mental disorder diagnosis; neurofibrillary tangles; tau proteins

Tau protein is was found to be elevated in the cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), reflecting neurofibrillary tangle formation. CSF tau concentrations, when combined with age in a discriminant function analysis, increased the power to maker a correct diagnosis of AD in subjects less than 70 years old. Interleukin 6 (IL-6) contributes to the interaction between immune mechanisms and brain. CSF concentrations from geriatric patients with major depression showed significantly reduced levels of both IL-6 and the soluble Il-6 receptor (sIL-6R), measured by enzyme-linked immunosorbant assays (ELISA), compared with control CSF.

发现在阿尔茨海默氏病（AD）患者的脑脊液（CSF）中，tau蛋白被升高，反映了神经纤维缠结的形成。 CSF TAU浓度与年龄在判别功能分析中结合在一起时，增加了使人在不到70年的受试者中正确诊断AD的能力。白介素6（IL-6）有助于免疫机制与大脑之间的相互作用。 与对照CSF相比，通过酶联的免疫吸收测定法（ELISA）测量的老年抑郁症患者的CSF浓度均显示出IL-6和可溶性IL-6受体（SIL-6R）的水平显着降低。