VISCERAL ADIPOSE TISSUE AND COLORECTAL NEOPLASIA

内脏脂肪组织和结直肠肿瘤

基本信息

批准号：
6376317
负责人：
ROBERT E. SCHOEN
金额：
$ 8.94万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-16 至 2002-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6376317
关键词：
adenomatous polyps adipose tissue cancer risk clinical research colorectal neoplasms computed axial tomography dietary lipid endoscopy gastrointestinal imaging /visualization human subject neoplasm /cancer epidemiology nutrition related neoplasm /cancer nutrition related tag obesity unsaturated fatty acids

项目摘要

Colorectal cancer (CRC) is a significant public health problem. Because treatment of advanced CRC is limited, prospects for CRC control must focus on early detection and prevention. Strong circumstantial evidence suggests that CRC develops from a precursor lesion, the adenomatous polyp. Because the number of individuals with polyps far exceeds the number who develop cancer, advances in CRC control must focus on improving our understanding of the risk factors for developing adenomas and for the transformation of adenomas into colorectal cancers. Obesity, estimated by body mass index, has been consistently linked to CRC risk in men but not in women. Recent epidemiologic data suggest that adipose tissue distribution, and in particular visceral adipose tissue (VAT) rather than overall adiposity, may be an important risk factor for CRC. Dietary fat, meat, and protein intake have also been postulated as risk factors for the CRC but studies have varied. For example, the benefits of polyunsaturated as opposed to saturated fat intake have not been observed in all studies. Previous investigations may have been hampered by using imprecise methodologies to measure obesity or estimate dietary fat intake. Biologic measures are preferable because of their greater precision. I propose to investigate the relationship of visceral adipose tissue and dietary fat intake to adenomatous polyps, the precursor lesion of CRC. Two well established biomarkers with superb reproducibility and successful pilot testing will be employed. Results from these studies will translate rapidly to clinical application and may impact significantly on future prevention efforts.

结直肠癌（CRC）是一个重大的公共卫生问题。由于晚期CRC的治疗有限，因此CRC的前景控制必须专注于早期检测和预防。强的间接证据表明，CRC从前体发展病变，腺瘤息肉。因为个人人数息肉远远超过了发展癌症的人数，进展 CRC控制必须集中于提高我们对风险的理解开发腺瘤和转化的因素腺瘤成结直肠癌。通过体重指数估计的肥胖症一直是一贯的与男性的CRC风险有关，但与女性无关。最近的流行病学数据表明脂肪组织分布，特别是内脏脂肪组织（增值税）而不是整体肥胖，可能是 CRC的重要危险因素。饮食脂肪，肉和蛋白质摄入还假定是CRC的风险因素，但研究有变化。例如，多不饱和的好处在所有研究中尚未观察到与饱和脂肪摄入相对的。以前的调查可能通过使用而受到阻碍不精确的方法来测量肥胖或估计饮食脂肪进气。生物学测量是可取的，因为它们的较大精确。我建议研究内脏的关系脂肪组织和饮食脂肪摄入腺瘤息肉， CRC的前体病变。两个建立了良好的生物标志物与将采用出色的可重复性和成功的试点测试。这些研究的结果将迅速转化为临床应用并可能对未来的预防工作产生重大影响。