PROGRAM TO DEVELOP RESEARCH IN IMMUNOLOGY OF AGING

衰老免疫学研究发展计划

• 批准号: 6372409
• 负责人: PAMELA L. WITTE
• 金额: $ 10.8万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6372409
• 关键词: aging; cell senescence; curriculum; developmental immunology; education evaluation /planning; health science research support; immunosenescence; interdisciplinary collaboration

The goal of the Academic Career Leadership Award is to solidify and enhance research and research training in the immunological aspects of aging at Loyola University Medical Center. The award will provide support for the research initiatives of the Immunology and Aging Program, based in the Department of Cell Biology, Neurobiology and Anatomy. The Immunology and Aging Program was initiated by the candidate and is comprised of several participating immunologists from multiple departments of Loyola Medical Center. The participating faculty members have developed a high level of interest in and active investigation into how the processes of aging and senescence affect immune function-including the initial development, production and senescence of lymphocytes; the regulation of immune responses by cytokines, antibodies, cell surface costimulatory molecules, and hormonal substances; and the recovery from burn trauma or wound. The hypothesis of our collective research is that aging leads to changes in the composition and regulation of the lymphocytes in immune tissues. We believe that investigation of immune aging and cell senescence are important frontiers for continued understanding of the basic principles of immune function in protection and disease. The Academic Career Leadership Award will be used by the candidate to enhance and promote interest in immunological aging research at Loyola Medical Center in order that this focus may excel in quality and funding support. The program is organized into three Specific Aims, which will meet this goal within the five year funding period. The first aim is to solidify and extend current preliminary studies by the group of investigators affiliated with the Immunology and Aging Program, allowing them to obtain successful RO1 grant funding. The program will promote collaborations among the investigators that will yield a program project application in the immunology of aging. The second aim of the program will foster new research endeavors into the immunology of aging, particularly interdisciplinary collaborations and collaborations between basic and clinical scientists at Loyola University Medical Center. The third aim will enhance research training opportunities in aging for graduate, medical, undergraduate, and minority high school students. In particular, the focus in graduate training will be toward building a graduate training tract in the immunological aspects of aging. This will be achieved by curriculum development and activities to enhance recruitment of student trainees. Loyola University Medical Center is an excellent institute for support of leadership activities in the aging and immunology. The institute has a strong, interactive immunology research community and strong interest in and commitment to expansion of research in aging.

学术职业领导力奖的目标是在洛约拉大学医学中心的衰老免疫学方面巩固和增强研究和研究培训。 该奖项将为基于细胞生物学，神经生物学和解剖学系的免疫学和衰老计划的研究计划提供支持。 免疫学和老化计划是由候选人发起的，由洛约拉医疗中心多个部门的几位参与免疫学家组成。 参与的教职员工对衰老和衰老过程如何影响免疫功能，包括最初发育，生产和衰老的淋巴细胞的衰老过程，对如何影响衰老和衰老过程产生了高度的兴趣和积极研究；通过细胞因子，抗体，细胞表面共刺激分子和激素物质来调节免疫反应；以及从烧伤创伤或伤口中恢复。我们集体研究的假设是，衰老会导致免疫组织中淋巴细胞组成和调节的变化。 我们认为，对免疫衰老和细胞衰老的研究是继续了解保护和疾病中免疫功能的基本原理的重要前沿。 候选人将使用学术职业领导力奖，以增强和促进洛约拉医学中心对免疫老化研究的兴趣，以便该重点在质量和资金支持方面表现出色。 该计划分为三个特定的目标，这将在五年的资金期内达到这一目标。 第一个目的是巩固和扩展与免疫学和老化计划相关的研究者小组的当前初步研究，从而使他们能够获得成功的RO1赠款资金。该计划将促进调查人员之间的合作，以在衰老免疫学中产生计划项目应用程序。 该计划的第二个目的将促进新的研究努力，促进衰老的免疫学，尤其是洛约拉大学医学中心基础科学家和临床科学家之间的跨学科合作和合作。 第三个目标将增强研究生，医学，本科和少数族裔高中生衰老的研究培训机会。 特别是，研究生培训的重点将是在衰老的免疫学方面建立研究生培训区。 这将通过课程开发和活动来实现，以增强学生学员的招聘。 洛约拉大学医学中心是支持老龄化和免疫学领导活动的出色研究所。 该研究所拥有强大的互动免疫学研究界，并对扩大衰老研究的浓厚兴趣和承诺。