IMMUN & IMMUNOCHEM CORE: ENVIRON MITE ALLERGENS: PUERTO RICAN ASTHMA DATABASE

免疫组化

• 批准号: 6205942
• 负责人: FEDERICO MONTEALEGRE
• 金额: $ 31.51万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205942
• 关键词: Hispanic Americans; Invertebrata; Mammalia

The Ponce School of Medicine proposes to expand our research capabilities by developing a Clinical Immunology-Immunochemistry Program. The objectives of such a program are to (I) initiate a long term multidisciplinary research effort oriented to bridge investigators in Basic and Clinical Sciences, (ii) provides stimulating and competitive research environment to faculty researchers in the area of clinical immunology, (iii) promote faculty development for up-to-date scientific technology, (iv) stimulate our faculty to develop the sense of adventure in new research directions in clinical immunology. Specifically, we intend to develop the basis for a long term project by expanding our research activities in three main areas that we have identified as key and the proposed program can be realistically accomplished. The areas which we are interested involve fungal pneumonitis, effects of cigarette smoking, emotional and surgical stress on the immune system. These areas offer excellent foundation for the proposed program. The proposal also aims to the creation of a research center, which will include the Laboratory of Immunochemistry and the Laboratory of Immunopharmacology. The clinical immunology program will include the existing laboratory of Virology. The Laboratory of Immunochemistry will be the base for the isolation and characterization of target antigens, peptide mapping, monoclonal antibodies, and amino acid sequencing and the development of synthetic peptides for use in immunodiagnosis. The laboratory of Immunopharmacology will be the base of the signaling transducing studies. The Laboratory of Virology will perform the immunoprofiles in target populations. The Laboratory of Immunochemistry will coordinate efforts in conjunction with the Laboratories of Virology and Immunopharmacology to accomplish the goals of the program.

庞塞医学院提议扩大我们的研究 通过开发临床免疫学-免疫化学能力 程序。 该计划的目标是 (I) 启动长期 面向桥梁的术语多学科研究工作 基础科学和临床科学的研究人员，(ii) 提供 为教师提供刺激和有竞争力的研究环境 临床免疫学领域的研究人员，(iii) 提升师资力量 发展最新的科学技术，（iv）激发我们的 教师培养新研究方向的冒险意识 在临床免疫学中。 具体来说，我们打算开发基础 通过将我们的研究活动扩展到三个方面来实现长期项目 我们确定为关键的主要领域以及拟议的计划可以 切实做到实事求是。 我们感兴趣的领域 涉及真菌性肺炎、吸烟的影响、情绪 以及手术对免疫系统的压力。 这些地区提供优秀的 拟议计划的基础。 该提案还旨在 建立一个研究中心，其中包括实验室 免疫化学和免疫药理学实验室。 这 临床免疫学项目将包括现有实验室 病毒学。 免疫化学实验室将成为该研究的基地 目标抗原的分离和表征、肽图分析、 单克隆抗体、氨基酸测序及其开发 用于免疫诊断的合成肽。 实验室 免疫药理学将成为信号转导的基础 研究。 病毒学实验室将进行免疫分析 在目标人群中。 免疫化学实验室将 与病毒学实验室合作协调工作 和免疫药理学来实现该计划的目标。