HPTN CENTRAL LABORATORY

HPTN 中心实验室

• 批准号: 6044327
• 负责人: Jay B Jackson
• 金额: $ 185.36万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6044327
• 关键词: 2'3' dideoxyinosine; AIDS; AIDS /HIV test; AIDS education /prevention; Candida albicans; Chlamydiaceae; HIV infections; Haemophilus; Neisseria gonorrhoeae; Treponema pallidum; Trichomonas vaginalis; bioassay; biomedical facility; clinical research; clinical trials; cooperative study; data management; delavirdine; experimental designs; flow cytometry; genetic techniques; genital herpes; human immunodeficiency virus 1; human papillomavirus; human subject; hydroxyurea; immunologic assay /test; indinavir; method development; microorganism culture; nonoxynol 9; pharmacokinetics; radioimmunoassay; sexually transmitted diseases; tissue /cell culture; tissue resource /registry; zidovudine

Johns Hopkins University (JHU) requests funding for the establishment of a Central Laboratory (CL) for the HIV Prevention Trials Network (HPTN). The JHU CL will be affiliating with the Coordinating and Operations Center (CORE) at Family Health International in Durham, NC and the Statistical and Data Management Center SDMC) at the Fred Hutchinson Cancer Research Center in Seattle, WA. Specific aims are the following: 1. Provide laboratory based scientific leadership and consultation to the HPTN collaborating organization and protocol teams. 2. Participate in the HPTN protocol development and review process. 3. Participate in the network management and establishment of the HPTN scientific agenda. 4. Provide processing, storage, and retrieval of domestic and international HPTN trial specimens. 5. Provide quality assurance for specimen processing, assay performance, and specimen related data transmission performed at the HIV Prevention Trial Unit (HPTU) sites. 6. Provide training and infrastructure support in laboratory QA, assay performance, and specimen shipping procedures at the HPTU clinical site laboratories. 7. Perform immunologic, pharmacologic, and virologic/bacteriologic testing for the HPTN protocols. 8. Develop and evaluate new assays for use in HPTN trials. 9. Coordinate procedures and timely transmission of accurate lab data to the HPTN SDMC. 10. Publish findings of new assay development/evaluation and pathogenesis based studies. To optimize the amount of scientific expertise and lab capabilities needed, the HPTN CL will be based on a hub and spoke concept involving JHU, University of Pittsburgh, and the California Public Health Dept (VRDL).

约翰·霍普金斯大学（JHU）要求为HIV预防试验网络（HPTN）建立中央实验室（CL）提供资金。 JHU CL将与北卡罗来纳州达勒姆国际卫生国际公司的协调与运营中心（CORE）以及华盛顿州西雅图市Fred Hutchinson癌症研究中心的统计和数据管理中心SDMC的统计和数据管理中心。具体目的是：1。向HPTN合作组织和协议团队提供基于实验室的科学领导力和咨询。 2。参加HPTN协议开发和审核过程。 3。参加HPTN科学议程的网络管理和建立。 4。提供国内和国际HPTN试验标本的处理，存储和检索。 5。为在HIV预防试验单元（HPTU）站点执行的标本处理，测定性能和标本相关的数据传输提供质量保证。 6.在HPTU临床现场实验室提供实验室质量检查，测定性能和标本运输程序的培训和基础设施支持。 7。对HPTN方案进行免疫，药理和病毒/细菌学测试。 8。开发和评估用于HPTN试验的新测定法。 9。坐标程序和及时将精确的实验室数据传输到HPTN SDMC。 10。发表新测定开发/评估和基于发病机理的研究结果。为了优化所需的科学专业知识和实验室能力，HPTN CL将基于枢纽，并涉及JHU，匹兹堡大学和加利福尼亚公共卫生部（VRDL）的概念。