ASSOCIATION OF NIPPLE ASPIRATES WITH CLINICAL FINDINGS

乳头抽吸术与临床结果的关联

• 批准号: 6675972
• 负责人: EDWARD R SAUTER
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-06 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6675972
• 关键词: biomarker; body fluids; breast neoplasm /cancer diagnosis; clinical research; cytodiagnosis; cytology; diagnosis design /evaluation; early diagnosis; female; fine needle aspiration; human subject; noninvasive diagnosis; preneoplastic state; tumor antigens; women's health

DESCRIPTION: (Applicant's Description) Mammography and physical examination are the only generally accepted screening tools available for breast cancer. Both are limited by the need to perform a diagnostic procedure to determine if the breast contains atypia or cancer. Present techniques to evaluate the breast for cancer comprise needle biopsies and procedures that encompass the entire lesion, including excisional biopsy and mastectomy. Each procedure has the risk of hematoma formation and infection. The former procedures are limited by sampling error, while the latter require an operative procedure, are costly and may raise concerns regarding cosmesis. Breast nipple aspiration, which provides nipple aspirate fluid (NAP), causes minimal or no discomfort, is noninvasive, quick, and provides both cells and extracellular fluid from the breast ductal epithelium, the cells which give rise to cancer. We are able to obtain NAP in over 99 percents of pre-and postmenopausal subjects, and have demonstrated that a biomarker in NAP is highly specific for the presence of residual cancer after excisional biopsy. Our objective is to assess if biomarkers in NAP can determine the benign or malignant nature of both nonpalpable and palpable breast lesions. If one or more biomarkers in NAP from women with an undiagnosed breast lesion proves to be highly sensitive and/or specific in determining whether precancer or cancer is present in the breast, then findings in NAP may allow the subject to forego an invasive diagnostic procedure and proceed directly to definitive surgery

描述：（申请人的描述） 乳房X线摄影和身体检查是唯一公认的筛查 可用于乳腺癌的工具。两者都受到执行需要的限制 诊断程序以确定乳房是否含有非典型或癌症。 目前评估癌症的技术包括针头活检 和涵盖整个病变的程序，包括移动活检 和乳房切除术。每个过程都有形成血肿的风险， 感染。以前的过程受到采样错误的限制，而 后者需要手术程序，昂贵，可能会引起人们的关注 关于宇宙。乳头乳头抽吸，可提供乳头抽吸物 流体（NAP）会导致最小或没有不适，无创，快速， 并从乳腺导管中提供细胞和细胞外液 上皮，引起癌症的细胞。我们能够在 绝经前和绝经后的99多个疾病，并已证明 午睡中的生物标志物对于存在残留癌的存在高度特异性 解剖活检后。我们的目标是评估午睡中的生物标志物是否可以 确定不可衡量和明显的良性或恶性本质 乳房病变。如果女性的午睡中的一个或多个生物标志物 未经诊断的乳房病变被证明是高度敏感和/或特异性的 确定乳房中是否存在癌症或癌症，然后 午睡中的发现可能使受试者放弃侵入性诊断 程序并直接进行确定手术

项目成果

Nipple aspirate cytology and pathologic parameters predict residual cancer and nodal involvement after excisional breast biopsy.

• DOI: 10.1054/bjoc.2001.2151
• 发表时间: 2001-12-14
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Sauter ER;Ehya H;Mammen A;Klein G
• 通讯作者: Klein G

Association of uPA, PAT-1, and uPAR in nipple aspirate fluid (NAF) with breast cancer.

乳头抽吸液 (NAF) 中的 uPA、PAT-1 和 uPAR 与乳腺癌的关联。

• DOI: 10.1097/00130404-200307000-00012
• 发表时间: 2003
• 期刊: Cancer journal (Sudbury, Mass.)
• 作者: Qin,Wenyi;Zhu,Weizhu;Wagner-Mann,Colette;Folk,William;Sauter,EdwardR
• 通讯作者: Sauter,EdwardR

Nipple aspirate fluid and ductoscopy to detect breast cancer.

• DOI: 10.1002/dc.21177
• 发表时间: 2010-04
• 期刊: DIAGNOSTIC CYTOPATHOLOGY
• 影响因子: 1.3
• 作者: Sauter, Edward R.;Klein-Szanto, Andres;MacGibbon, Brenda;Ehya, Hormoz
• 通讯作者: Ehya, Hormoz

Ethnic variation in kallikrein expression in nipple aspirate fluid.

乳头抽吸液中激肽释放酶表达的种族差异。

• DOI: 10.1002/ijc.10556
• 发表时间: 2002
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Sauter,EdwardR;Welch,Tamara;Magklara,Angeliki;Klein,Gary;Diamandis,EleftheriosP
• 通讯作者: Diamandis,EleftheriosP

Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.

乳头抽吸液中激肽释放酶表达与乳腺癌风险的关联。

• DOI: 10.1002/ijc.11607
• 发表时间: 2004
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Sauter,EdwardR;Lininger,John;Magklara,Angelika;Hewett,JohnE;Diamandis,EleftheriosP
• 通讯作者: Diamandis,EleftheriosP