LEPROSY RESEARCH SUPPORT

麻风病研究支持

• 批准号: 6334063
• 负责人: PATRICK J BRENNEN
• 金额: $ 42.65万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-29 至 2002-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334063
• 关键词: Mycobacterium leprae; biomedical resource; leprosy

The objective is to facilitate research in leprosy by provision of research materials, prepared from purified Mycobacterium Leprae to qualified basic and clinical research scientists. The M. leprae organisms are prepared from tissue taken from infected armadillos. Materials prepared from these tissues include intact [killed] whole M. leprae cells and a variety of sub cellular materials. These include purified antigens, proteins, polysaccharides, lipids, nucleic acids, and other sub cellular materials and fractions.

目的是通过提供以下材料来促进麻风病研究 研究材料，由纯化的麻风分枝杆菌制备 合格的基础和临床研究科学家。麻风分枝杆菌生物体 由取自受感染犰狳的组织制备而成。材料 由这些组织制备的包括完整的[杀死的]整个麻风分枝杆菌细胞 以及各种亚细胞材料。这些包括纯化的抗原， 蛋白质、多糖、脂质、核酸和其他亚细胞 材料和分数。

项目成果

Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.

麻风分枝杆菌和结核分枝杆菌培养滤液蛋白 10 的 B 和 T 细胞表位的比较分析。

• DOI: 10.1128/iai.72.6.3161-3170.2004
• 发表时间: 2004
• 期刊: Infection and immunity
• 影响因子: 3.1
• 作者: Spencer,JohnS;Kim,HeeJin;Marques,AngelaM;Gonzalez-Juarerro,Mercedes;Lima,MonicaCBS;Vissa,VaralakshmiD;Truman,RichardW;Gennaro,MariaLaura;Cho,Sang-Nae;Cole,StewartT;Brennan,PatrickJ
• 通讯作者: Brennan,PatrickJ

Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis.

麻风分枝杆菌 34 千道尔顿蛋白的表征，该蛋白与副结核分枝杆菌的免疫显性 34 千道尔顿抗原同源。

• DOI: 10.1128/iai.66.11.5576-5579.1998
• 发表时间: 1998
• 期刊: Infection and immunity
• 影响因子: 3.1
• 作者: Silbaq,FS;Cho,SN;Cole,ST;Brennan,PJ
• 通讯作者: Brennan,PJ

Vaccination of mice against the leprosy bacillus with skin-test antigens.

用皮试抗原对小鼠进行麻风杆菌疫苗接种。

• 发表时间: 1999
• 期刊: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
• 作者: Ngamying,M;Levy,L;Brennan,PJ
• 通讯作者: Brennan,PJ

Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae.

麻风分枝杆菌酚糖脂-I 的肽模拟表位的产生和表征。

• DOI: 10.1016/j.femsim.2004.01.001
• 发表时间: 2004
• 期刊: FEMS immunology and medical microbiology
• 作者: Youn,JuHo;Myung,Han-Jeong;Liav,Abraham;Chatterjee,Delphi;Brennan,PatrickJ;Choi,In-Hong;Cho,Sang-Nae;Shin,Jeon-Soo
• 通讯作者: Shin,Jeon-Soo

Effects of vaccination with several mycobacterial proteins and lipoproteins on Mycobacterium leprae infection of the mouse.

接种几种分枝杆菌蛋白和脂蛋白对小鼠麻风分枝杆菌感染的影响。

• 发表时间: 2001
• 期刊: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
• 作者: Ngamying,M;Varachit,P;Phaknilrat,P;Levy,L;Brennan,PJ;Cho,SN
• 通讯作者: Cho,SN