EFFECTS OF DECREASED HYPERINSULINEMIA ON THE OVULATORY RESPONSE TO CLOMIPHENE

降低高胰岛素血症对克罗米芬排卵反应的影响

• 批准号: 6307511
• 负责人: WILLIAM S EVANS
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307511
• 关键词: clinical research; clomiphene; drug screening /evaluation; female; hormone regulation /control mechanism; human subject; human therapy evaluation; insulin; metformin; ovulation; polycystic ovary syndrome; reproductive system disorder chemotherapy; reproductive system pharmacology

This is a study of the effects of reducing insulin concentrations on ovulation while taking the medication, clomiphene citrate. Insulin concentrations will be reduced using the medication, metformin. We know that many women with the polycystic ovary syndrome (PCOS) do not ovulate spontaneously and often do not respond well to a drug commonly used to induce ovulation known as clomiphene citrate. We also know that many women with polycystic ovary syndrome have elevated insulin concentrations in their blood. If insulin levels are reduced with diet and exercise, women with PCOS often begin to ovulate spontaneously. However, many women with PCOS find it very difficult to lose enough weight and/or exercise enough to lower their insulin levels. Metformin is a drug that has been shown to lower insulin levels and, therefore, may prove to be useful in treating women with the polycystic ovary syndrome who desire fertility. We hope to learn whether women with the polycystic ovary syndrome and who have failed to ovulate in response to conventional doses of clomiphene citrate will have a higher rate of clomiphene citrate-stimulated ovulation when serum insulin levels are reduced.

这是一项研究服用克罗米芬柠檬酸盐药物时降低胰岛素浓度对排卵的影响。 使用药物二甲双胍可以降低胰岛素浓度。 我们知道，许多患有多囊卵巢综合症 (PCOS) 的女性不会自发排卵，并且通常对常用的促排卵药物克罗米芬柠檬酸盐的反应不佳。 我们还知道，许多患有多囊卵巢综合症的女性血液中的胰岛素浓度升高。 如果通过饮食和运动降低胰岛素水平，患有多囊卵巢综合症的女性通常会开始自发排卵。 然而，许多患有多囊卵巢综合症的女性发现很难减轻足够的体重和/或进行足够的锻炼来降低胰岛素水平。二甲双胍是一种已被证明可以降低胰岛素水平的药物，因此可能被证明可用于治疗渴望生育的多囊卵巢综合症女性。我们希望了解，当血清胰岛素水平降低时，患有多囊卵巢综合征且对常规剂量的克罗米芬柠檬酸盐未能排卵的女性是否会具有更高的克罗米芬柠檬酸盐刺激排卵率。