NEW YORK UNIVERSITY WOMEN'S HEALTH STUDY

纽约大学女性健康研究

• 批准号: 6305941
• 负责人: Paolo G. Toniolo
• 金额: $ 2.1万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305941
• 关键词: androgens; breast neoplasms; cancer risk; clinical research; colon neoplasms; disease /disorder etiology; estrogens; female; gonadotropins; hormone regulation /control mechanism; human data; human tissue; neoplasm /cancer; nutrition aspect of cancer; ovary neoplasms; uterus neoplasms; women's health

The author has recruited a cohort of 15,800 women, ages 35-65, who have donated a sample of venous blood at entry in order to create a blood bank. After 64,000 person-years of followup, more than 600 cases of invasive cancers have been identified, 309 of which have been breast cancer. Of note, there has been a strong association of serum estrogens and the development of breast cancer. The investigator proposes to continue to follow the cohort prospectively in order to continue to investigate the role of reproductive hormones in cancer etiology ( breast, ovarian, endometrial and large intestine) in women. The role of estrogens, androgens and gonadotropins, as well as the relationships of hormones and diet will be correlated to the development and risk of cancer. The CDMAS computer is necessary for the volume and analysis of data.

作者招募了 15,800 名年龄在 35 岁至 65 岁之间的女性，她们在入院时捐献了静脉血样本，以建立血库。经过 64,000 人年的随访，已发现 600 多例浸润性癌症病例，其中 309 例是乳腺癌。值得注意的是，血清雌激素与乳腺癌的发生密切相关。研究人员建议继续前瞻性跟踪该队列，以继续研究生殖激素在女性癌症病因（乳腺癌、卵巢癌、子宫内膜癌和大肠癌）中的作用。雌激素、雄激素和促性腺激素的作用以及激素和饮食的关系与癌症的发生和风险相关。 CDMAS 计算机对于数据量和分析是必需的。