CORE--PATIENT ACCESS, DATA MANAGEMENT AND TISSUE CULTURE

核心——患者访问、数据管理和组织培养

• 批准号: 6325769
• 负责人: RICHARD A LARSON
• 金额: $ 26.66万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-27 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6325769
• 关键词: biomedical facility; blood /lymphatic neoplasm; cancer registry /resource; clinical research; data management; human subject; statistics /biometry; tissue /cell culture; tissue resource /registry

Therapy-related leukemia is a late complication of treatment with cytotoxic drugs and/or irradiation. It is a distinctive clinicopathological and cytogenetic syndrome that is usually fatal. One of the special features of this program is that the four individual projects are absolutely dependent upon patient material, since most of the questions to be addressed arise from the nature of individual patient responses. That is, why do some patients develop secondary leukemia and others not? In addition to patient enrollment, chart review, specimen collection and data acquisition, we propose again to incorporate within the original Core formal support for database coordination, statistical analysis, and computation. In addition, we propose to expand our studies on genetic susceptibility for the development of leukemia by establishing a registry of primary and secondary leukemia families in order to ascertain familial aggregations. The Patient Access core has the dual missions of specimen acquisition and data management and analysis. These functions are critical to the successful completion of the proposed investigations and necessary to support and link together the results that will come from the various laboratories. In this way, interim analyses of data may be disseminated promptly among the project investigators, and unique patient resources may be shared in the most productive manner. In order to provide an orderly access to patient material and to maintain records, we propose to continue our Core component to manage these functions as it has for the past 10 years. Requests for specific clinical materials (blood or marrow cells, tumor tissues, DNA from buccal swabs, or cell lines from specific patients or family members) will be directed by each project PI to the Core. After collection, the clinical specimens will be logged in and transported for processing and delivery to the individual projects. Data forms will be kept in secure file cabinets, and research data will be maintained in electronic files under password security.

治疗相关性白血病是治疗的晚期并发症 细胞毒性药物和/或辐射。这是一种独特的临床病理学 和通常致命的细胞遗传学综合征。 特别的之一 该计划的特点是四个单独的项目是 绝对取决于患者材料，因为大多数问题 需要解决的问题源于个体患者反应的性质。 也就是说，为什么有些患者会发展为继发性白血病，而另一些患者会发展为继发性白血病？ 不是？ 除了患者登记、图表审查、标本采集 和数据采集，我们再次建议将其纳入原来的 对数据库协调、统计分析和 计算。 此外，我们建议扩大遗传研究 通过建立登记册来确定患白血病的易感性 原发性和继发性白血病家族的调查，以确定家族史 聚合。 Patient Access 核心具有样本采集的双重使命 以及数据管理和分析。 这些功能对于 成功完成拟议的调查并有必要 支持并将来自各个方面的结果联系在一起 实验室。 通过这种方式，可以传播数据的中期分析 项目研究者的及时反馈以及独特的患者资源 可以以最富有成效的方式进行共享。 为了有序地获取患者材料并保持 记录，我们建议继续使用我们的核心组件来管理这些 功能与过去 10 年一样。 特定临床要求 材料（血细胞或骨髓细胞、肿瘤组织、口腔拭子 DNA、 或来自特定患者或家庭成员的细胞系）将被定向 由每个项目 PI 到核心。 临床标本采集后 将被登录并传输以进行处理并交付给 个人项目。 数据表格将保存在安全的文件柜中，并且 研究数据将保存在密码下的电子文件中 安全。