VALIDATION OF FAMILY HISTORY OF CANCER QUESTIONNAIRE

癌症家族史问卷的验证

• 批准号: 6356467
• 负责人: MARY M MASTERS
• 金额: $ 94.32万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356467
• 关键词: Medicare /Medicaid; breast neoplasms; cancer registry /resource; cancer risk; case history; clinical research; colorectal neoplasms; data collection methodology /evaluation; family genetics; genetic susceptibility; human data; lung neoplasms; neoplasm /cancer epidemiology; neoplasm /cancer genetics; ovary neoplasms; prostate neoplasms; questionnaires

This methodologic study will provide estimates of the accuracy of family history of cancer reports in a general population setting, which will help to evaluate the feasibility of future surveillance studies of genetic risk factors for cancer. A family history of cancer questionnaire will be developed and administered to a probability sample of approximately 1600 residents in the state of Connecticut. The questionnaire will ascertain the occurrence of cancer in the respondents' first and second degree relatives. Positive and negative reports of major cancers, including breast, prostate, lung, colorectal, and ovarian cancers, will be validated by searching state tumor registry records and other data sources (i.e., Medicare records, National Death Index files or death certificates, and physician reports)in order to determine the sensitivity and specificity of family history reports. Some additional epidemiologic and psychosocial variables will be collected to examine possible predictors of reporting accuracy and completeness.

这项方法学研究将提供对一般人群中癌症家族史报告准确性的估计，这将有助于评估未来癌症遗传风险因素监测研究的可行性。将制定一份癌症家族史调查问卷，并针对康涅狄格州约 1600 名居民的概率样本进行调查。调查问卷将确定受访者的一级和二级亲属是否患有癌症。主要癌症（包括乳腺癌、前列腺癌、肺癌、结直肠癌和卵巢癌）的阳性和阴性报告将通过搜索州肿瘤登记记录和其他数据源（即医疗保险记录、国家死亡指数文件或死亡证明以及医生）进行验证。报告）以确定家族史报告的敏感性和特异性。将收集一些额外的流行病学和心理社会变量，以检查报告准确性和完整性的可能预测因素。