Double blind, randomised controlled trial assessing the efficacy of endothelin-1 receptor antagonism in preventing peri-procedural myonecrosis in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention

双盲、随机对照试验，评估内皮素 1 受体拮抗剂预防接受经皮冠状动脉介入治疗的非 ST 抬高急性冠状动脉综合征患者围手术期肌坏死的功效

• 批准号: nhmrc : 1094045
• 负责人: Dr Kevin Liou
• 金额: $ 8.31万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/double-blind-randomised-coronary-intervention/519471
• 关键词: Double; blind; randomised; controlled; trial

While the focus in the treatment of coronary artery disease has primarily been on the large vessels in the heart, vessels of small calibre may also play a significant role in patients with angina, heart attack, and muscle injury related to a stenting procedure.This project aims elucidate the possible mechanisms which cause dysfunction in these small vessels. I also hope to find a treatment strategy which may benefit patients with small vessel problems and thus improve their overall outcome.

虽然治疗冠状动脉疾病的重点主要是心脏中的大血管，但小口径的血管也可能在心绞痛，心脏病发作和与支架手术相关的肌肉损伤的患者中起重要作用。该项目旨在阐明这些小容器中可能引起功能障碍的可能机制。我还希望找到一种治疗策略，该策略可能使小血管问题的患者受益，从而改善其整体结果。