METABOLIC IMPLICATIONS OF DIETARY ARGININE SUPPLEMENTS

膳食精氨酸补充剂的代谢影响

• 批准号: 6123142
• 负责人: Peter James Garlick
• 金额: $ 7.84万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123142
• 关键词: arginine; cell proliferation; clinical research; dietary aminoacid; dietary supplements; human subject; human tissue; neoplasm /cancer surgery; nutrition aspect of cancer; nutrition related tag; postoperative state; protein biosynthesis; wound healing

The effects of dietary supplements of arginine (30 g/d for 3 d) on protein synthesis and cell proliferation in malignant tumors and normal tissues are being investigated in cancer patients and healthy volunteers. Preliminary studies have suggested that the two-fold stimulation of protein synthesis and Ki67 expression by arginine previously observed in breast tumors might not occur in other tumors or healthy tissues. Arginine supplements are therefore being given to cancer patients for 3d prior to surgery, and tissue and tumor samples are being collected during the operation. Similar patients without dietary supplements serve as controls. Patients with cancer of the prostate, breast, colon and bladder are currently being investigated. Future studies will also include lung cancer, as well as protein synthesis in blood lymphocytes of healthy volunteers.

正在癌症患者和健康志愿者中研究精氨酸膳食补充剂（30克/天，持续3天）对恶性肿瘤和正常组织中蛋白质合成和细胞增殖的影响。 初步研究表明，先前在乳腺肿瘤中观察到的精氨酸对蛋白质合成和 Ki67 表达的双重刺激可能不会发生在其他肿瘤或健康组织中。 因此，癌症患者在手术前补充精氨酸 3 天，并在手术过程中收集组织和肿瘤样本。 没有膳食补充剂的类似患者作为对照。 目前正在对患有前列腺癌、乳腺癌、结肠癌和膀胱癌的患者进行研究。 未来的研究还将包括肺癌以及健康志愿者血液淋巴细胞中的蛋白质合成。