PATHOBIOLOGY OF UTERINE LEIOMYOMAS (FIBROIDS)

子宫平滑肌瘤（肌瘤）的病理学

• 批准号: 6289903
• 负责人: DARLENE DIXON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289903
• 关键词: animal tissue; apoptosis; carcinogenesis; cellular pathology; environmental toxicology; female; growth factor receptors; histochemistry /cytochemistry; human tissue; leiomyoma; neoplastic growth; proliferating cell nuclear antigen; smooth muscle; tissue /cell culture; transforming growth factors; uterus neoplasms

Summary of Work: The Comparative Pathobiology Group has focused its research on defining the pathogenesis/carcinogenesis of disorders affecting the reproductive tract of humans and rodents, and assessing the role of environmental and endogenous factors in the induction of these disorders. Our group has used archival mouse and human tissues to determine the presence of growth factors in uterine leiomyomas (fibroids) and leiomyosarcomas in mice and women. Data from our studies show that TGF-a (mature form) is expressed exclusively in malignant uterine smooth muscle cell tumors (leiomyosarcomas) of mice. However, in benign uterine smooth muscle cell tumors (leiomyomas) of mice and women this growth factor is not present. Also, uterine LS in women do not express TGF-a. In mice, we have also found a positive correlation between TGF-a staining and immunoexpression of epidermal growth factor receptor, and increased cell proliferation as measured by the expression of proliferating cell nuclear antigen (PCNA) in the malignant uterine leiomyosarcomas. Studies to assess the immunoexpression of factors (Bcl- 2; Bax) possibly modulating cell survival and death in human uterine leiomyomas show that both positive and negative regulatory proteins of programmed cell death (apoptosis) are present in uterine leiomyomas in women, and that apoptosis does not appear to play a significant role in the development of these tumors. - Leiomyomas, Uterus, Fibroids, Pathobiology

工作摘要：比较病理生物学小组将其研究集中在定义影响人类和啮齿动物生殖道的疾病的发病机理/癌变上，并评估环境和内源性因素在诱导这些疾病中的作用。我们的小组已经使用档案小鼠和人体组织来确定小鼠和女性的子宫平滑肌瘤（肌瘤）和平滑肌肉瘤的生长因子的存在。我们研究的数据表明，TGF-A（成熟形式）仅在小鼠的恶性子宫平滑肌细胞肿瘤（平滑肌肉瘤）中表达。但是，在小鼠和女性的良性子宫平滑肌细胞肿瘤（平滑肌瘤）中，这种生长因子不存在。另外，女性的子宫LS也不表达TGF-A。在小鼠中，我们还发现了表皮生长因子受体的TGF-A染色与免疫表达之间存在正相关，并增加了通过恶性子宫静脉体肉瘤中增殖细胞核抗原（PCNA）表达来测量的细胞增殖。评估因子静脉瘤的细胞生存和死亡的因素（BCL-2; BAX）的免疫表达的研究表明，在女性的子宫静脉膜中，女性的阳性细胞死亡（凋亡）阳性和阴性调节蛋白都存在，并且凋亡在这些themors的发展中都没有发挥重要作用。 - 平滑肌瘤，子宫，肌瘤，病理生物学