ASSESSMENT OF LYMPHOCYTES IN PATIENTS WITH AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROM

自身免疫性淋巴细胞增殖综合征患者的淋巴细胞评估

• 批准号: 6289482
• 负责人: thomas a fleisher
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289482
• 关键词: B lymphocyte; T lymphocyte; autoimmune disorder; clinical research; genetic disorder; human subject; immunopathology diagnosis; lymphocyte proliferation; surface antigens

An extensive evaluation flow cytometric evaluation continues of patients with autoimmune lymphoproliferative syndrome (ALPS) and their extended-family members. The evaluation is based on characterization of the expanded double negative T-cell and B-cell populations. To date, the double negative T-cells have been demonstrated to be alpha beta TcR, CD57+, HLA-DR+, and CD45RA+. This study has been extended to characterize the double negative T cells more completely including gamma-delta TcR T cells in all ALPS patients. In addition, expanded characterization of the B cells in these patients has also been initiated.

对自身免疫性淋巴增殖综合征 (ALPS) 患者及其大家庭成员的广泛流式细胞术评估仍在继续。该评估基于扩展的双阴性 T 细胞和 B 细胞群的表征。迄今为止，双阴性T细胞已被证明是αβTcR、CD57+、HLA-DR+和CD45RA+。这项研究已扩展到更全面地表征所有 ALPS 患者中的双阴性 T 细胞，包括 γ-δ TcR T 细胞。此外，还开始对这些患者的 B 细胞进行扩展表征。