CORE--CLINICAL ASSESSMENT

核心——临床评估

• 批准号: 6299269
• 负责人: YAAKOV STERN
• 金额: $ 32.23万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6299269
• 关键词: African American; Hispanic Americans; Medicare /Medicaid; Parkinson's disease; aging; behavioral /social science research tag; biomedical facility; caucasian American; cerebrovascular disorder diagnosis; clinical research; cognition; dementia; functional ability; human old age (65+); human subject; interview; longitudinal human study; magnetic resonance imaging; medical outreach /case finding; mental disorder diagnosis; mental health epidemiology; neuropsychological tests; racial /ethnic difference; stroke

This core will recruit , screen, and perform diagnostic evaluations on participants to be included in the other projects. This core will continue to follow participants recruited in the previous funding cycle (1992 cohort). In addition, 2000 new participants (1999 cohort) will be recruited to supplement the existing cohort. Like the 1992 cohort, the 1999 cohort will be recruited from an enumerated listing of Medicare recipients provided to us by the Health Care Finance Administration (HCFA). Evaluation procedures will parallel those of the previous funding cycle. At each visit, all participants receive a detailed interview to assess cognitive and functional impairment and a neuropsychological evaluation. Subjects screening positive for stroke, Parkinson's disease, or cognitive impairment also will receive a standardized medical and neurological evaluation. Data from all subjects are reviewed at a diagnostic consensus conference of neurologists and neuropsychologists. The diagnosis of dementia is made based upon evidence of cognitive impairment on neuropsychological testing and functional impairment sufficient to interfere with social or occupational functioning. It a participant is demented than the cause of dementia will be specified further. Cranial MRI scanning has been added to better assess the contribution of cerebrovascular disease in incident dementia cases. The severity of cognitive deficit in non-demented subjects also is rated. We will continue to examine the influence of sociocultural factors on our diagnostic paradigm. We have incorporated measures of educational experience and literacy into this core to permit assessment of these variables on our diagnostic process.

该核心将对参与者进行招募、筛选和诊断评估，以纳入其他项目。该核心将继续跟踪上一个资助周期（1992 年队列）招募的参与者。此外，还将招募 2000 名新参与者（1999 年队列）来补充现有队列。与 1992 年队列一样，1999 年队列将从医疗保健财务管理局 (HCFA) 向我们提供的 Medicare 受益人枚举名单中招募。评估程序将与上一个资助周期的程序类似。每次访问时，所有参与者都会接受详细的访谈，以评估认知和功能障碍以及神经心理学评估。中风、帕金森病或认知障碍筛查呈阳性的受试者也将接受标准化的医学和神经学评估。所有受试者的数据均在神经科医生和神经心理学家的诊断共识会议上进行审查。痴呆症的诊断是基于神经心理学测试中的认知障碍证据和足以干扰社交或职业功能的功能障碍。如果参与者患有痴呆症，则将进一步具体说明痴呆症的原因。增加了头颅 MRI 扫描，以更好地评估脑血管疾病在痴呆病例中的作用。还对非痴呆受试者认知缺陷的严重程度进行了评估。我们将继续研究社会文化因素对我们诊断范式的影响。我们已将教育经验和读写能力的衡量标准纳入这一核心，以便在我们的诊断过程中评估这些变量。