VAGAL TONE AND SOCIAL OUTCOME IN AT RISK CHILDREN

高危儿童的迷走神经张力和社会结果

基本信息

批准号：
6344479
负责人：
STEPHEN J SHEINKOPF
金额：
$ 3.24万
依托单位：
EMMA PENDLETON BRADLEY HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-08-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6344479
关键词：
autonomic reflex behavioral /social science research tag caregivers child rearing clinical research disease /disorder proneness /risk embryo /fetus toxicology heart function heart innervation heart rate human subject infant human (0-1 year) longitudinal human study prenatal stress preschool child (1-5) social behavior social behavior disorders vagus nerve

项目摘要

DESCRIPTION: (Applicant's Abstract) Utilizing a longitudinal design and drawing subjects from a large ongoing study, this investigation will examine the relations between cardiovascular reactivity in infancy and social and behavioral outcomes in an at-risk group of children. In so doing, the study will examine the predictive role of cardiac reactivity (i.e., vagal tone) to specifically social stimuli in infancy to specifically social outcomes at 3-years of age. In addition, this study will investigate the role of caregiver stress and dysfunction in potentially moderating the relations between infant cardiac reactivity and 3-year outcome. To date, few if any studies have examined relations between cardiac reactivity and behavioral outcome in at-risk children. Participants will include approximately 1,000 drug-exposed children who have been observed on a regular basis from birth through three years of age. The design is longitudinal and will utilize measures from three separate domains: cardiac reactivity in infancy, 2) a cumulative index of risks present in the caregiving environment, and 3) a cumulative index of social and behavioral risk outcomes at 3-years of age. Analyses will address two main goals. First, domain-specific relations between cardiac reactivity to social and nonsocial events in infancy and social and nonsocial competence in preschool will be examined. Second, the relation of caregiving risk to social and behavioral outcomes will be examined. In particular, this second set of analyses will examine the potential interaction of cardiac reactivity and caregiving factors in predicting social and behavioral outcomes.

描述：（申请人的摘要）利用纵向设计并从正在进行的大型研究中抽取受试者，本研究将检查婴儿期心血管反应性与高危儿童群体的社会和行为结果之间的关系。在此过程中，该研究将检验心脏反应性（即迷走神经张力）对婴儿期特定社会刺激对 3 岁时特定社会结果的预测作用。此外，本研究将调查看护者压力和功能障碍在潜在调节婴儿心脏反应性和 3 年结局之间关系中的作用。迄今为止，很少有研究探讨高危儿童的心脏反应性与行为结果之间的关系。参与者将包括大约 1,000 名接触毒品的儿童，他们从出生到三岁都受到定期观察。该设计是纵向的，将利用来自三个不同领域的测量：婴儿期的心脏反应性，2）护理环境中存在的风险累积指数，以及3）3岁时社会和行为风险结果的累积指数。分析将解决两个主要目标。首先，将检查婴儿期心脏对社会和非社会事件的反应性与学前班社会和非社会能力之间的特定领域关系。其次，将研究护理风险与社会和行为结果的关系。特别是，第二组分析将检查心脏反应性和护理因素在预测社会和行为结果方面的潜在相互作用。