TCD Assessment of Hemovelocity while Older Adults Think

老年人思考时 TCD 评估 Hemovelocity

• 批准号: 6314972
• 负责人: ALBERT E ROBERTS
• 金额: $ 8.25万
• 依托单位: CATAWBA COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314972
• 关键词: age difference; blood flow measurement; brain circulation; brain imaging /visualization /scanning; clinical research; cognition; human subject

This research plan is guided by two goals: (a) to determine if cognitive activities known to modulate cerebral hemovelocity in young adults induce comparable changes in older, stroke-free persons, and (b) to document time-course modulations in hemovelocity that emerge while older persons perform these activities. These goals lead to two specific objectives: (1) verify the effects of individual cognitive activities or. the velocities of younger persons, and (2) document the effects of the same cognitive activities on velocities of older, stroke-free persons. To accomplish these objectives, three experiments will use a transcranial Doppler neuroimaging procedure to record bilateral cerebral blood flow velocity simultaneously while persons perform cognitive activities. The cognitive tasks model day-to- day thinking activities and will be selected from short-term remembering, envisaging a persona experience, making decisions, studying stimuli, and solving problems that are language based, nonlanguage based, or quantitative. Two experiments will follow two-way factorial designs, with repeated measures on insonation side (right and left) and cognitive phases (relevant baselines and specific tasks). The middle cerebral artery of young adults (Experiment 1) and older, stroke-free persons (Experiment 2) will be sampled while they perform 7-to-9, 31-sec cognitive tasks within. a 30-min test session. The third experiment will expand to a three-way factorial design by adding cerebral arteries (middle, anterior, posterior) as a factor. The arteries of the same older, stroke-free persons will be sampled to compare relative velocity differences that may emerge during the cognitive activities. Attainment of the two goals will provide a repertoire of cognitive probes to practitioners serving as adjuncts to traditional functional tests in assessing the temporal resiliency to the cerebrovascular autoregulation mechanisms of older persons, including those who may show cerebrovascular dysfunction.

该研究计划以两个目标为指导：（a）确定年轻人中已知的认知活动是否可以调节脑血义性，导致老年人，无卒中的人的可比变化，以及（b）记录在老年人执行这些活动时出现的血伏的时间效率调节。这些目标导致了两个具体的目标：（1）验证单个认知活动的影响或。年轻人的速度，以及（2）记录相同的认知活动对年龄较大的无中风速度的影响。为了实现这些目标，三个实验将使用经颅多普勒神经影像学手术同时记录双侧脑血流速度，而人进行认知活动。认知任务模拟日常思考活动，并将从短期记忆中选择，设想角色体验，做出决策，研究刺激以及解决基于语言，非语言或定量的问题。两个实验将遵循双向阶乘设计，并重复进行调节侧（左右）和认知阶段（相关基线和特定任务）进行重复测量。年轻人的中部动脉（实验1）及以上的无中风的人（实验2）将在内部执行7至9，31秒的认知任务时进行采样。一个30分钟的测试。第三个实验将通过将脑动脉（中部，前，后部）添加为一个因素，将其扩展为三向阶乘设计。将对同一老年人，无中风的人的动脉进行采样，以比较认知活动期间可能出现的相对速度差异。实现两个目标将为从业人员评估老年人的脑血管自动调节机制的时间弹性，包括可能表现出脑血管功能障碍的老年人，为传统功能测试提供认知探针的曲目。