WORKER MONITORING TESTS FOR CARPAL TUNNEL SYNDROME

工人腕管综合症监测测试

基本信息

批准号：
6334833
负责人：
ROBERT G RADWIN
金额：
$ 14.57万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-01 至 2002-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6334833
关键词：
carpal tunnel syndrome clinical research computer assisted diagnosis diagnosis design /evaluation human subject industrial medicine nervous system disorder diagnosis psychological tests psychomotor function

项目摘要

DESCRIPTION (Adapted From the Investigator's Abstract): This proposal investigates using a battery of psychomotor and sensory tests for periodically monitoring industrial workers for subtle functional deficits associated with carpal tunnel syndrome (CTS). Although these tests are not intended for diagnosis, they should be sufficiently sensitive to detect early CTS deficits, yet be more specific for CTS than other monitoring instruments, such as self-reported or structured symptom surveys. Since these tests are automated and non-invasive, they may be suitable for routinely monitoring workers for early CTS, analogous to how audiometric tests are used for monitoring workers exposed to loud acoustic noise. Monitoring instruments are needed for active surveillance, for early detection of CTS before these cases progress into costly and disabling occupational illnesses, and for triggering ergonomics interventions. The Principal Investigator has already developed the biomedical instrumentation for this proposal. The tests were demonstrated to be reliable and sensitive for detection of psychomotor and sensory deficits associated with CTS. These tests were correlated with median nerve electrophysiologic parameters in a case-control study involving outpatients with electrophysiologically confirmed CTS, and a control group free of symptoms and electrodiagnostic parameters consistent with CTS. The proposal advances that work by proposing a prospective study for investigating if temporal changes in these test parameters can be observed among workers developing CTS symptoms. An industrial population of 250 workers exposed to risk factors associated with CTS from a variety of industries associated with high CTS incidence rates will be periodically tested for changes in psychomotor and sensory functional test parameters over a four year period. Workers will annually undergo examination for CTS, including electrophysiologic testing. Outcomes having positive/negative functional changes and positive/negative self reported symptoms will be ascertained and sensitivity, specificity and predictive value will be compared. In addition to these field investigations, new parameters for these instruments will be investigated using outpatient subjects and controls.

描述（改编自研究者的摘要）：本提案研究使用一系列精神运动和感觉测试定期监测产业工人的细微功能缺陷与腕管综合症（CTS）有关。虽然这些测试并不用于诊断时，它们应该足够敏感以检测早期 CTS 缺陷，但 CTS 比其他监测更具体工具，例如自我报告或结构化症状调查。自从这些测试是自动化且非侵入性的，它们可能适合定期监测工人的早期 CTS，类似于听力测试测试用于监测暴露在大声噪音下的工人。需要监测仪器来进行主动监测，以便及早发现在这些病例发展成代价高昂且致残之前检测到 CTS 职业病，并触发人体工程学干预。首席研究员已经开发出生物医学该提案的仪器。测试被证明是可靠且灵敏地检测精神运动和感觉缺陷与 CTS 相关。这些测试与正中神经相关涉及门诊患者的病例对照研究中的电生理参数电生理学证实的 CTS，对照组不含症状及电诊断参数与CTS一致。提案通过提出一项前瞻性研究来调查是否可以取得进展可以在工人中观察到这些测试参数的时间变化出现 CTS 症状。 250 名工业工人暴露于来自各个行业的与 CTS 相关的风险因素 CTS 发病率高的情况下，将定期检测其变化四年期间的精神运动和感觉功能测试参数。工人每年都会接受 CTS 检查，包括电生理测试。具有正/负功能的结果将确定变化和阳性/阴性自我报告症状将比较敏感性、特异性和预测值。此外根据这些现场调查，这些仪器的新参数将被确定使用门诊受试者和对照进行调查。