HORMONAL INTERACTION WITH AGING BRAIN

荷尔蒙与大脑老化的相互作用

基本信息

批准号：
6129273
负责人：
JANICE M JURASKA
金额：
$ 7.17万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-15 至 2002-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6129273
关键词：
Golgi apparatus aging dendrites estrogens female hippocampus hormone regulation /control mechanism laboratory rat menstrual cycle ovariectomy prefrontal lobe /cortex

项目摘要

As the proportion of post-menopausal women in the population has increased, hormone replacement has become increasingly commonplace. Recently, research has suggested that estrogens and progestins can affect higher order, cognitive behaviors when used in replacement after menopause and in their fluctuations during the menstrual cycle. Estrogens also appear to delay the onset of Alzheimer's disease, as well as modulate schizophrenic symptoms. An animal model of these effects would be useful in understanding how the ovarian steroids influence parts of the nervous system dealing with higher cognitive functions through the lifespan. The long term goal of this research is to explore the effects of ovarian steroids on cognitive behavior and concomitant neural substrates in the cycling and aging female rat. Before commencing on large and detailed studies with hormone manipulations, preliminary data are sought to select which neural area upon which to concentrate. The effects of the estropausal state of the aging rat and the phase of the cycle in young adult females on spine densities and dendritic field extent will be examined. Two cognitively relevant areas will be sampled: the hippocampus and the medial prefrontal cortex. There is preliminary data that spine densities drop precipitously with age (28-40 percent) in the medial prefrontal cortex. If this area is sensitive to ovarian hormones in aging, it would be an excellent model for age related changes in female anatomy and behavior. If it is relatively refractory to ovarian steroids, changes in the medial prefrontal cortex would be a useful model for general aging effects in both sexes.

随着年绝经后妇女在人口中的比例增加，激素替代已经变得越来越普遍。最近，研究表明，雌激素和孕激素在更年期后替换时会影响高阶，认知行为，并在月经周期中发生波动。雌激素似乎也延迟了阿尔茨海默氏病的发作，并调节了精神分裂症症状。这些作用的动物模型将有助于理解卵巢类固醇如何影响神经系统的一部分，该神经系统在整个生命周期内处理较高的认知功能。这项研究的长期目标是探索卵巢类固醇对骑自行车和衰老的女性大鼠认知行为和随之而来的神经底物的影响。在开始进行激素操纵的大型研究研究之前，寻求初步数据以选择要集中的神经区域。将检查老年大鼠雌性雌激素状态的影响以及年轻成年女性的循环对脊柱密度和树突状田地的影响。将采样两个认知相关区域：海马和内侧前额叶皮层。有初步数据，脊柱密度随内侧前额叶皮层的年龄（28-40％）急剧下降。如果该区域对衰老中的卵巢激素敏感，则将是女性解剖学和行为相关的变化的绝佳模型。如果它对卵巢类固醇相对难治性，则内侧前额叶皮层的变化将是两种性别中一般衰老作用的有用模型。