BIOBEHAVIORAL MODEL OF STRESS AND MULTIPLE SCLEROSIS

压力和多发性硬化症的生物行为模型

• 批准号: 2674498
• 负责人: KURT D ACKERMAN
• 金额: $ 13.51万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674498
• 关键词: behavioral /social science research tag; behavioral medicine; clinical research; coping; disease /disorder proneness /risk; human subject; longitudinal human study; model design /development; multiple sclerosis; neuroendocrine system; psychological models; psychological stressor; psychoneuroimmunology; social behavior; social support network; socioeconomics; stress

The applicant has a long-standing interest in behavioral medicine research, with particular emphasis on the role of stress and mental health in the development of medical disorders. He has received an M.D. and Ph.D. in Neurobiology and Anatomy and is Board Certified in General Psychiatry. His previous research has involved identification of communication, routes between the central nervous system (CNS) and the rodent immune system, which may be involved m stress-related immune changes and the development of immune-mediated disorders. This Mentored Research Scientist Development Award is designed to provide him with the skills necessary to pursue his long-term goals of conducting longitudinal human studies of stress-related health changes, understanding the psychological and biological factors which govern this relationship, and developing appropriate treatment strategies for prevention of stress-related medical illness. To achieve these goals, the applicant has proposed a series of career development activities and research studies under the mentorship of Dr. Andrew Baum, exploring the role of stress in the autoimmune disorder multiple sclerosis (MS). MS is one of the most common neurologic disorders, produced by immune-mediated destruction of the CNS. Since the earliest descriptions of MS, stress has been considered an important factor contributing to the progression of the disorder; however, there have been few systematic studies in this area. During the award period, the candidate will conduct a prospective longitudinal study of stress and health in MS patients, while monitoring mental health and biological factors which may play a role in stress- related exacerbations. This research experience will be supplemented by career development activities supervised by pioneering researchers at the University of Pittsburgh, Ohio State University, University of Chicago, and University of California, Los Angeles. The proposed training program is designed to develop the candidate's expertise in: 1) longitudinal study design and analysis; 2) autonomic and neuroendocrine regulation of the immune system; 3) use of animal models of autoimmune disorders; 4) statistical modeling of stress and disease; and 5) the development of interventions for stress-related medical disorders directed at physical and mental health; and will give him the skills necessary to pursue an independent academic career in behavioral medicine research.

申请人对行为医学有着长期的兴趣 研究，特别强调压力和心理健康的作用 在医学疾病的发展中。他获得了医学博士和博士学位。 拥有神经生物学和解剖学博士学位，并获得普通精神病学委员会认证。 他之前的研究涉及通信、路线识别 中枢神经系统（CNS）和啮齿动物免疫系统之间， 这可能与压力相关的免疫变化和发育有关 免疫介导的疾病。这指导了研究科学家的发展 奖项旨在为他提供追求他的职业所需的技能 进行与压力相关的纵向人体研究的长期目标 健康变化，了解心理和生物因素 控制这种关系，并制定适当的治疗方法 预防与压力相关的疾病的策略。 为了实现这些目标，申请人提出了一系列的职业规划 在博士的指导下进行开发活动和研究。 Andrew Baum，探索压力在自身免疫性疾病中的作用 多发性硬化症（MS）。 MS 是最常见的神经系统疾病之一 由免疫介导的中枢神经系统破坏而产生的疾病。自从 在对 MS 的最早描述中，压力被认为是一个重要的因素 导致疾病进展的因素；然而，有 这方面的系统研究还很少。 颁奖期间，候选人将进行前瞻性 对多发性硬化症患者的压力和健康状况进行纵向研究，同时监测 可能在压力中发挥作用的心理健康和生物因素 相关的恶化。这项研究经验将得到补充 由先驱研究人员监督的职业发展活动 匹兹堡大学、俄亥俄州立大学、芝加哥大学、 和加州大学洛杉矶分校。拟议的培训计划 旨在培养候选人在以下方面的专业知识：1）纵向研究 设计与分析； 2）植物神经和神经内分泌的调节 免疫系统; 3）使用自身免疫性疾病动物模型； 4） 压力和疾病的统计模型； 5）发展 针对与压力相关的医学疾病的干预措施，针对身体 和心理健康；并将给予他必要的技能来追求 行为医学研究的独立学术生涯。