PURIFICATION OF HEPATIC STEM CELLS

肝干细胞的纯化

• 批准号: 6280917
• 负责人: HYAM L LEFFERT
• 金额: $ 0.36万
• 依托单位: UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280917
• 关键词: animal tissue; biomedical resource; biotechnology; liver

We are extending our preliminary results of hepatic stem cell purification by using the multiparameter flow cytometric analysis and cell sorting system The system is used to characterize and purify viable hepatic stem cells obtained from rats treated with allyl alcohol. These cells will provide powerful practical and conceptual tools to solve problems of liver organogenesis, function and carcinogenesis. Knowledge gained from this work will facilitate similar studies with human liver tissue. Hepatic stem cells might also serve as key components of regulated multicellular bioreactors. These devices will provide liver function for patients with acute or chronic liver failure.

我们正在扩展肝干细胞的初步结果 使用多参数流式细胞分析进行纯化 细胞分选系统 该系统用于表征和纯化 从用烯丙基治疗的大鼠中获得的活肝干细胞 酒精。 这些单元将提供强大的实践和概念 解决肝脏器官发生、功能和功能问题的工具 致癌作用。 从这项工作中获得的知识将有助于 对人类肝脏组织的类似研究。 肝干细胞可能 也作为调节多细胞生物反应器的关键组件。 这些设备将为患有急性或慢性疾病的患者提供肝功能。 慢性肝功能衰竭。